Antagonism of pro-2-PAM using central and peripheral anticholinergic drugs
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Date
2011-10-19
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Department
Towson University. Department of Psychology
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There are no restrictions on access to this document. An internet release form signed by the author to display this document online is on file with Towson University Special Collections and Archives.
There are no restrictions on access to this document. An internet release form signed by the author to display this document online is on file with Towson University Special Collections and Archives.
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Abstract
The goal of this study was two-fold. Experiment 1 characterized the intoxicating tremor produced by two known tremor-inducing drugs, oxotremorine and physostigmine in order to characterize the tremoregenic effects of a centrally acting oxime, pro-2-PAM. Pro-2-PAM crosses the blood brain barrier and may have therapeutic value against OP intoxication. Experiment 2 attempted to antagonize the tremor produced by 28.0 mg/kg of pro-2-PAM with a Med Associates System using central and peripheral anticholinergics. The centrally acting anticholinergics were atropine sulfate and scopolamine HBr; the peripherally acting anticholinergics were AMN and SMN. In Experiment 1, the only drugs that showed a tremoregenic effect against their controls were oxotremorine and physostigmine. A high dose of physostigmine (0.4 mg/kg) induced more tremor than 0.1 mg/kg of oxotremorine; only 0.1 mg/kg of oxotremorine induced more tremor than 28.0 mg/kg of pro-2-PAM. In Experiment 2, only the centrally acting anticholinergics reduced the tremoregenic effect of pro-2-PAM.