Microneedle-Assisted Skin Permeation by Non-toxic Bioengineerable Gas Vesicle Nanoparticles
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2017
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Abhay U. Andar, Ram Karan, Wolf T. Pecher, Priya DasSarma, William D. Hedrich, Audra L. Stinchcomb, and Shiladitya DasSarma. Microneedle-Assisted Skin Permeation by Nontoxic Bioengineerable Gas Vesicle Nanoparticles. Molecular Pharmaceutics 2017 14 (3), 953-958.
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Abstract
Gas vesicle nanoparticles (GVNPs) are hollow, buoyant protein organelles produced by the extremophilic microbe Halobacterium sp. NRC-1 and are being developed as bioengineerable and biocompatible antigen and drug-delivery systems (DDS). Dynamic light scattering measurements of purified GVNP suspensions showed a mean diameter of 245 nm. In vitro diffusion studies using Yucatan miniature pig skin showed GVNP permeation to be enhanced after MN-treatment compared to untreated skin. GVNPs were found to be non-toxic to mammalian cells (human kidney and rat mycocardial myoblasts). These findings support the use of GVNPs as DDS for intradermal/transdermal permeation of protein- and peptide-based drugs.