Effects of head-only or whole-body exposure to very low doses of ⁴ He (1000 MeV/n) particles on neuronal function and cognitive performance
| dc.contributor.author | M.Rabin, Bernard | |
| dc.contributor.author | M.Poulose, Shibu | |
| dc.contributor.author | Bielinski, Donna F. | |
| dc.contributor.author | Shukitt-Hale, Barbara | |
| dc.date.accessioned | 2019-02-28T18:31:08Z | |
| dc.date.available | 2019-02-28T18:31:08Z | |
| dc.date.issued | 2019-02 | |
| dc.description.abstract | On exploratory class missions, astronauts will be exposed to a range of heavy particles which vary in linear energy transfer (LET). Previous research has shown a direct relationship between particle LET and cognitive performance such that, as particle LET decreases the dose needed to affect cognitive performance also decreases. Because a significant portion of the total dose experienced by astronauts may be expected to come from exposure to low LET ⁴ He particles, it would be important to establish the threshold dose of ⁴ He particles that can produce changes in cognitive performance. The results indicated that changes in neuronal function and cognitive performance could be observed following both head-only and whole-body exposures to ⁴ He particles at doses as low as 0.01–0.025 cGy. These results, therefore, suggest the possibility that astronauts on exploratory class missions may be at a greater risk for HZE-induced deficits than previously anticipated. | en_US |
| dc.description.sponsorship | This research was supported by NASA Grants: NNX13AB73G and NNX16AE06G. | en_US |
| dc.description.uri | https://www.sciencedirect.com/science/article/pii/S2214552418300786 | en_US |
| dc.format.extent | 8 pages | en_US |
| dc.genre | journal articles postprints | en_US |
| dc.identifier | doi:10.13016/m2dgxk-ugdl | |
| dc.identifier.citation | Bernard M. Rabin , Shibu M. Poulose, Donna F. Bielinski , Barbara Shukitt-Hale, Effects of head-only or whole-body exposure to very low doses of ⁴ He (1000 MeV/n) particles on neuronal function and cognitive performance, Life Sciences in Space Research , Volume 20, February 2019, Pages 85-92, https://doi.org/10.1016/j.lssr.2019.02.001 | en_US |
| dc.identifier.uri | https://doi.org/10.1016/j.lssr.2019.02.001 | |
| dc.identifier.uri | http://hdl.handle.net/11603/12895 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Elsevier Ltd | en_US |
| dc.relation.isAvailableAt | The University of Maryland, Baltimore County (UMBC) | |
| dc.relation.ispartof | UMBC Psychology Department Collection | |
| dc.relation.ispartof | UMBC Faculty Collection | |
| dc.rights | This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author. | |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) | * |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.rights.uri | Access to this item will begin on February 28, 2021 | * |
| dc.subject | behavior | en_US |
| dc.subject | oxidative stress | en_US |
| dc.subject | neuroinflamation | en_US |
| dc.title | Effects of head-only or whole-body exposure to very low doses of ⁴ He (1000 MeV/n) particles on neuronal function and cognitive performance | en_US |
| dc.type | Text | en_US |