xnd-1 Regulates the Global Recombination Landscape in C. elegans

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dc.contributor.authorWagner, Cynthia R.
dc.contributor.authorKuervers, Lynnette
dc.contributor.authorBaillie, David
dc.contributor.authorYanowitz, Judith L.
dc.date.accessioned2019-05-23T15:13:49Z
dc.date.available2019-05-23T15:13:49Z
dc.date.issued2010-10-14
dc.description.abstractMeiotic crossover (CO) recombination establishes physical linkages between homologous chromosomes that are required for their proper segregation into developing gametes and promotes genetic diversity by shuffling genetic material between parental chromosomes. COs require the formation of double strand breaks (DSBs) to create the substrate for strand exchange. DSBs occur in small intervals called hotspots1-3 and significant variation in hotspot usage exists between and among individuals4. This variation is thought to reflect differences in sequence identity and chromatin structure, DNA topology and/ or chromosome domain organization1, 5-9. Chromosomes show different frequencies of nondisjunction (NDJ)10, reflecting inherent differences in meiotic crossover control, yet the underlying basis of these differences remains elusive. Here we show that a novel chromatin factor, X non-disjunction factor 1 (xnd-1), is responsible for the global distribution of COs in C. elegans. xnd-1 is also required for formation of double-strand breaks (DSBs) on the X, but surprisingly XND-1 protein is autosomally-enriched. We show that xnd-1 functions independently of genes required for X chromosome-specific gene silencing, revealing a novel pathway that distinguishes the X from autosomes in the germ line, and further show that xnd-1 exerts its effects on COs, at least in part, by modulating levels of H2A lysine 5 acetylation.en_US
dc.description.sponsorshipThis work was supported by the Carnegie Institution of Washington, NIH K01AG031296, and MWRI start-up funds to J.L.Y.en_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045774/en_US
dc.format.extent14 pagesen_US
dc.genrejournal articles postprintsen_US
dc.identifierdoi:10.13016/m2sfko-hmnl
dc.identifier.citationCynthia R. Wagner, Lynnette Kuervers, David Baillie, and Judith L. Yanowitz, xnd-1 Regulates the Global Recombination Landscape in C. elegans, Nature. 2010 Oct 14; 467(7317): 839–843. doi: 10.1038/nature09429en_US
dc.identifier.urihttps://dx.doi.org/10.1038%2Fnature09429
dc.identifier.urihttp://hdl.handle.net/11603/13925
dc.language.isoen_USen_US
dc.publisherSpringer Nature Publishing AGen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjectmeiotic crossoveren_US
dc.subjectchromosomesen_US
dc.subjectXND-1 proteinen_US
dc.subjectdouble strand breaks (DSBs)en_US
dc.titlexnd-1 Regulates the Global Recombination Landscape in C. elegansen_US
dc.typeTexten_US

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