Autogenous control of the S10 ribosomal protein operon of Escherichia coli: genetic dissection of transcriptional and posttranscriptional regulation

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dc.contributor.authorFreedman, L. P.
dc.contributor.authorZengel, J. M.
dc.contributor.authorArcher, R. H.
dc.contributor.authorLindahl, L.
dc.date.accessioned2019-06-05T17:37:24Z
dc.date.available2019-06-05T17:37:24Z
dc.date.issued1987-09
dc.description.abstractThe S10 ribosomal protein operon is regulated autogenously by the product of one of the genes of the operon, the gene encoding ribosomal protein L4. We have used site-directed mutagenesis to isolate leader mutations affecting L4 control. The phenotypes of these mutants demonstrate that L4 regulates both transcription and translation of the S10 operon. Several mutations abolish both levels of L4 control; others eliminate either transcriptional or translational control with little or no effect on the other mode of regulation. We conclude that L4-mediated transcriptional and translational control share some sequence requirements, but the two regulatory processes recognize somewhat different features of the S10 leader. Primary as well as secondary structures within the S10 leader appear to be involved.en_US
dc.description.sponsorshipThis work was supported by a Public Health Service grant and a Research Career Development Award (to L.L.) from the National Institute for Allergy and Infectious Diseases.en_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC299108/en_US
dc.format.extent5 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2kcly-naxy
dc.identifier.citationL P Freedman, J M Zengel, R H Archer, and L Lindahl, Autogenous control of the S10 ribosomal protein operon of Escherichia coli: genetic dissection of transcriptional and posttranscriptional regulation, Proc Natl Acad Sci U S A. 1987 Sep; 84(18): 6516–6520. doi: 10.1073/pnas.84.18.6516en_US
dc.identifier.urihttps://dx.doi.org/10.1073%2Fpnas.84.18.6516
dc.identifier.urihttp://hdl.handle.net/11603/14019
dc.language.isoen_USen_US
dc.publisherNational Academy of Sciencesen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjectribosomal protein operonen_US
dc.subjectEscherichia colien_US
dc.subjectL4-mediated transcriptionalen_US
dc.titleAutogenous control of the S10 ribosomal protein operon of Escherichia coli: genetic dissection of transcriptional and posttranscriptional regulationen_US
dc.typeTexten_US

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