Biomimetic Strategies To Treat Traumatic Brain Injury by Leveraging Fibrinogen

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dc.contributor.authorBrown, Ashley C.
dc.contributor.authorLavik, Erin
dc.contributor.authorStabenfeldt, Sarah E.
dc.date.accessioned2019-11-13T18:03:43Z
dc.date.available2019-11-13T18:03:43Z
dc.date.issued2019-06-27
dc.description.abstractThere were over 27 million new cases of traumatic brain injuries (TBIs) in 2016 across the globe. TBIs are often part of complicated trauma scenarios and may not be diagnosed initially because the primary clinical focus is on stabilizing the patient. Interventions used to stabilize trauma patients may inadvertently impact the outcomes of TBIs. Recently, there has been a strong interest in the trauma community toward administrating fibrinogen-containing solutions intravenously to help stabilize trauma patients. While this interventional shift may benefit general trauma scenarios, fibrinogen is associated with potentially deleterious effects for TBIs. Here, we deconstruct what components of fibrinogen may be beneficial as well as potentially harmful following TBI and extrapolate this to biomimetic approaches to treat bleeding and trauma that may also lead to better outcomes following TBI.en_US
dc.description.sponsorshipNIH NIAMS (Grant R21AR071017; A.C.B.), NSF CAREER DMR (Grant 1847488; A.C.B.), NIH NINDS (Grant R56NS100732; E.L.), NIH NICHD (Grant DP2HD084067; S.E.S.), and NSF CAREER CBET (Grant 1454282; S.E.S.).en_US
dc.description.urihttps://pubs.acs.org/doi/10.1021/acs.bioconjchem.9b00360en_US
dc.format.extent6 pagesen_US
dc.genrejournal articles postprintsen_US
dc.identifierdoi:10.13016/m27g7x-jwzq
dc.identifier.citationAshley C. Brown, Erin Lavik, and Sarah E. Stabenfeldt, Biomimetic Strategies To Treat Traumatic Brain Injury by Leveraging Fibrinogen, Bioconjugate Chemistry 2019 30 (7), 1951-1956 DOI: 10.1021/acs.bioconjchem.9b00360en_US
dc.identifier.urihttp://hdl.handle.net/11603/16284
dc.language.isoen_USen_US
dc.publisherACS Publicationsen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemical, Biochemical & Environmental Engineering Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsAccess to this item will begin on 2020-06-27
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Bioconjugate Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see: https://pubs.acs.org/doi/abs/10.1021/acs.bioconjchem.9b00360
dc.subjectbiomimetic strategiesen_US
dc.subjectfibrinogenen_US
dc.subjecttraumatic brain injuryen_US
dc.subjecttraumaen_US
dc.titleBiomimetic Strategies To Treat Traumatic Brain Injury by Leveraging Fibrinogenen_US
dc.typeTexten_US

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