Copy Number Alterations on Human Chromosomes 21 Associated with Prostate Cancer

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dc.contributor.authorHalloran, Fiona
dc.contributor.departmentBiological Sciencesen_US
dc.date.accessioned2020-02-24T20:35:17Z
dc.date.available2020-02-24T20:35:17Z
dc.date.issued2018
dc.description.abstractThe goal of my thesis project was incorporate my skills of computational biology, genomics, computer science and mathematics into something that would contribute to the knowledge of the scientific community and public in a useful way. In pairing with Dr. Philip Anderson, I was able to accomplish this goal. The research I pursued was focused on identifying potential regions of importance in prostate tumorigenesis. I analyzed publically available from The Cancer Genome Atlas using the programs R, Perl, and Bash. The code I wrote mined the data of the patients' chromosome 21 DNA, specifically copy number variants. The output of interest was the sums of patients who had a deletion or insertion at every nucleotide. I plotted this to find regions on chromosome 21 where insertion or deletion was prevalent. The region of greatest deletion was in an intron of a gene, and I used this information to hypothesize possible explanations for the regions' involvement in prostate cancer growth. My findings will hopefully allow other scientists to better understand the mechanisms of prostate cancer and inspire them to continue what I just began to uncover.en_US
dc.format.extent17 pagesen_US
dc.genrethesesen_US
dc.identifierdoi:10.13016/m2vpa9-fxrf
dc.identifier.urihttp://hdl.handle.net/11603/17370
dc.language.isoen_USen_US
dc.relation.isAvailableAtSalisbury Universityen_US
dc.subjectChromosomesen_US
dc.subjectProstate canceren_US
dc.titleCopy Number Alterations on Human Chromosomes 21 Associated with Prostate Canceren_US
dc.typeTexten_US

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