Hydrolytically degradable poly(ethylene glycol) hydrogel scaffolds with tunable degradation and mechanical properties

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dc.contributor.authorZustiak, Silviya P.
dc.contributor.authorLeach, Jennie B.
dc.date.accessioned2018-12-11T15:49:50Z
dc.date.available2018-12-11T15:49:50Z
dc.date.issued2010-05-10
dc.description.abstractThe objective of this work was to create three-dimensional (3D) hydrogel matrices with defined mechanical properties, as well as tunable degradability for use in applications involving protein delivery and cell encapsulation. Thus, we report the synthesis and characterization of a novel hydrolytically degradable poly(ethylene glycol) (PEG) hydrogel composed of PEG vinyl sulfone (PEG-VS) cross-linked with PEG-diester-dithiol. Unlike previously reported degradable PEGbased hydrogels, these materials are homogeneous in structure, fully hydrophilic and have highly specific cross-linking chemistry. We characterized hydrogel degradation and associated trends in mechanical properties, i.e., storage modulus (G′), swelling ratio (QM), and mesh size (ξ). Degradation time and the monitored mechanical properties of the hydrogel correlated with crosslinker molecular weight, cross-linker functionality, and total polymer density; these properties changed predictably as degradation proceeded (G′ decreased, whereas QM and ξ increased) until the gels reached complete degradation. Balb/3T3 fibroblast adhesion and proliferation within the 3D hydrogel matrices were also verified. In sum, these unique properties indicate that the reported degradable PEG hydrogels are well poised for specific applications in protein and cell delivery to repair soft tissue.en_US
dc.description.sponsorshipThis work was supported by NIH-NINDS (R01NS065205), the Henry Luce Foundation and UMBC.en_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050024/en_US
dc.format.extent24 pagesen_US
dc.genrejounal articlesen_US
dc.identifierdoi:10.13016/M2KP7TW1J
dc.identifier.citationSilviya P. Zustiak and Jennie B. Leach, Hydrolytically Degradable Poly(Ethylene Glycol) Hydrogel Scaffolds with Tunable Degradation and Mechanical Properties, Biomacromolecules, 2010, 11 (5), pp 1348–1357 DOI: 10.1021/bm100137qen_US
dc.identifier.uri10.1021/bm100137q
dc.identifier.urihttp://hdl.handle.net/11603/12218
dc.language.isoen_USen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemical, Biochemical & Environmental Engineering Department Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjecttissue engineeringen_US
dc.subjectdegradationen_US
dc.subject3D scaffolden_US
dc.subjectcell viabilityen_US
dc.subjectpoly(ethylene glycol) (PEG)en_US
dc.titleHydrolytically degradable poly(ethylene glycol) hydrogel scaffolds with tunable degradation and mechanical propertiesen_US
dc.typeTexten_US

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