Biochemical and Hematological Correlates of Elevated Homocysteine in National Surveys

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dc.contributor.advisorUMBC Student Collection
dc.contributor.authorBeydoun, May A.
dc.contributor.authorBeydoun, Hind A.
dc.contributor.authorMacIver, Peter H.
dc.contributor.authorHossain, Sharmin
dc.contributor.authorCanas, Jose A.
dc.contributor.authorEvans, Michele K.
dc.contributor.authorZonderman, Alan B.
dc.date.accessioned2020-05-20T14:59:36Z
dc.date.available2020-05-20T14:59:36Z
dc.date.issued2020-03-30
dc.description.abstractElevated blood homocysteine (Hcy) among middle-aged adults can increase age-related disease risk, possibly through other biochemical and hematological markers. We selected markers for hyperhomocysteinemia among middle-aged adults, studied time-dependent Hcy-marker associations and computed highly predictive indices of hyperhomocysteinemia, with cross-sectional and longitudinal validations. We used data from the National Health and Nutrition Examination Survey (NHANES III, phase 2, nmax = 4000), the NHANES 1999–2006 (nmax = 10,151) and pooled NHANES (cross-sectional validation). Longitudinal validation consisted of mixed-effects linear regression models (Hcy predicting markers’ annual rates of change), applied to the Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS, n = 227–244 participants, k = 2.4 repeats/participant, Agebase: 30–65 years) data. Machine learning detected nine independent markers for Hcy > 14 µmol/L (NHANES III, phase 2): older age; lower folate and B-12 status; higher serum levels of creatinine, uric acid, alkaline phosphatase, and cotinine; mean cell hemoglobin and red cell distribution widths (RDW); results replicated in the 1999–2006 NHANES [AUC = 0.60–0.80]. Indices combining binary markers increased elevated Hcy odds by 6.9–7.5-fold. In HANDLS, first-visit Hcy predicted annual increase in creatinine, RDW and alkaline phosphatase, with third-visit index (2013–2018) directly predicting Hcy (2004–2009). We provide evidence of the internal and external validity of indices composed of several biomarkers that are strongly associated with elevated Hcy.en_US
dc.description.sponsorshipWe would like to thank Megan Williams and Nicolle Mode (NIA/NIH/IRP) for internally reviewing our manuscript. The authors declare no conflict of interest. This work was supported in part by the Intramural Research Program of the NIH, National institute on Aging.en_US
dc.description.urihttps://www.mdpi.com/2072-6643/12/4/950en_US
dc.format.extent22 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2anrh-uahv
dc.identifier.citationMay A. Beydoun et al., Biochemical and Hematological Correlates of Elevated Homocysteine in National Surveys and a Longitudinal Study of Urban Adults, Nutrients 2020, 12(4), 950; https://doi.org/10.3390/nu12040950en_US
dc.identifier.urihttps://doi.org/10.3390/nu12040950
dc.identifier.urihttp://hdl.handle.net/11603/18677
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Psychology Department Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.titleBiochemical and Hematological Correlates of Elevated Homocysteine in National Surveysen_US
dc.typeTexten_US

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