The Eyes Have It: Regulatory and Structural Changes Both Underlie Cichlid Visual Pigment Diversity

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dc.contributorNoor, Mohamed A. F.
dc.contributor.authorHofmann, Christopher M.
dc.contributor.authorO’Quin, Kelly E.
dc.contributor.authorMarshall, N. Justin
dc.contributor.authorCronin, Thomas W.
dc.contributor.authorSeehausen, Ole
dc.contributor.authorCarleton, Karen L.
dc.date.accessioned2019-04-11T18:39:52Z
dc.date.available2019-04-11T18:39:52Z
dc.date.issued2009-12-22
dc.description.abstractA major goal of evolutionary biology is to unravel the molecular genetic mechanisms that underlie functional diversification and adaptation. We investigated how changes in gene regulation and coding sequence contribute to sensory diversification in two replicate radiations of cichlid fishes. In the clear waters of Lake Malawi, differential opsin expression generates diverse visual systems, with sensitivities extending from the ultraviolet to the red regions of the spectrum. These sensitivities fall into three distinct clusters and are correlated with foraging habits. In the turbid waters of Lake Victoria, visual sensitivity is constrained to longer wavelengths, and opsin expression is correlated with ambient light. In addition to regulatory changes, we found that the opsins coding for the shortest- and longest-wavelength visual pigments have elevated numbers of potentially functional substitutions. Thus, we present a model of sensory evolution in which both molecular genetic mechanisms work in concert. Changes in gene expression generate large shifts in visual pigment sensitivity across the collective opsin spectral range, but changes in coding sequence appear to fine-tune visual pigment sensitivity at the shortand long-wavelength ends of this range, where differential opsin expression can no longer extend visual pigment sensitivity.en_US
dc.description.sponsorshipFunding for this work was provided to KC by the University of Maryland and the National Science Foundation, IBN 0131285, 0654076, 0841270; and to OS by the Swiss National Science Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.description.urihttps://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1000266en_US
dc.format.extent13 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2a250-twuw
dc.identifier.citationHofmann CM, O’Quin KE, Marshall NJ, Cronin TW, Seehausen O, et al. (2009) The Eyes Have It: Regulatory and Structural Changes Both Underlie Cichlid Visual Pigment Diversity. PLoS Biol 7(12): e1000266. doi:10.1371/journal.pbio.1000266en_US
dc.identifier.urihttps://doi.org/10.1371/journal.pbio.1000266
dc.identifier.urihttp://hdl.handle.net/11603/13402
dc.language.isoen_USen_US
dc.publisherPLOSen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsAttribution 3.0 United States (CC BY 3.0 US)*
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/us/*
dc.subjectCichlid visual pigment diversityen_US
dc.subjectLake Victoriaen_US
dc.subjectopsinsen_US
dc.subjectsensory evolutionen_US
dc.subjectmolecular genetic mechanismsen_US
dc.titleThe Eyes Have It: Regulatory and Structural Changes Both Underlie Cichlid Visual Pigment Diversityen_US
dc.typeTexten_US

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