Microneedle-Assisted Skin Permeation by Non-toxic Bioengineerable Gas Vesicle Nanoparticles
| dc.contributor.author | Andar, Abhay | |
| dc.contributor.author | Karan, Ram | |
| dc.contributor.author | Pecher, Wolf T | |
| dc.contributor.author | Dassarma, Priya | |
| dc.contributor.author | Hedrich, William | |
| dc.contributor.author | Stinchcomb, Audra L | |
| dc.contributor.author | Dassarma, Shiladitya | |
| dc.date.accessioned | 2017-06-23T19:31:18Z | |
| dc.date.available | 2017-06-23T19:31:18Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | Gas vesicle nanoparticles (GVNPs) are hollow, buoyant protein organelles produced by the extremophilic microbe Halobacterium sp. NRC-1 and are being developed as bioengineerable and biocompatible antigen and drug-delivery systems (DDS). Dynamic light scattering measurements of purified GVNP suspensions showed a mean diameter of 245 nm. In vitro diffusion studies using Yucatan miniature pig skin showed GVNP permeation to be enhanced after MN-treatment compared to untreated skin. GVNPs were found to be non-toxic to mammalian cells (human kidney and rat mycocardial myoblasts). These findings support the use of GVNPs as DDS for intradermal/transdermal permeation of protein- and peptide-based drugs. | en_US |
| dc.format.extent | 6 pages | en_US |
| dc.genre | journal articles | en_US |
| dc.identifier | doi:10.13016/M2K35MD15 | |
| dc.identifier.citation | Abhay U. Andar, Ram Karan, Wolf T. Pecher, Priya DasSarma, William D. Hedrich, Audra L. Stinchcomb, and Shiladitya DasSarma. Microneedle-Assisted Skin Permeation by Nontoxic Bioengineerable Gas Vesicle Nanoparticles. Molecular Pharmaceutics 2017 14 (3), 953-958. | en_US |
| dc.identifier.uri | 10.1021/acs.molpharmaceut.6b00859 | |
| dc.identifier.uri | http://hdl.handle.net/11603/4185 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.relation.isAvailableAt | University of Baltimore | |
| dc.title | Microneedle-Assisted Skin Permeation by Non-toxic Bioengineerable Gas Vesicle Nanoparticles | en_US |
| dc.type | Text | en_US |
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