Chemiluminescent solid lipid nanoparticles (SLN) and interations with intact skin
dc.contributor.author | Breidenich, Jennifer | |
dc.contributor.author | Patrone, Julia | |
dc.contributor.author | Kelly, Lisa | |
dc.contributor.author | Benkoski, Jason | |
dc.contributor.author | Le, Huong | |
dc.contributor.author | Sample, Jennifer | |
dc.date.accessioned | 2019-02-05T16:30:28Z | |
dc.date.available | 2019-02-05T16:30:28Z | |
dc.date.issued | 2009-08-24 | |
dc.description | SPIE NanoScience + Engineering, 2009, San Diego, California, United States | |
dc.description.abstract | We report the synthesis and characterization of a novel nanoparticle formulation designed for skin penetration for the purpose of skin imaging. Solid lipid nanoparticles (SLNs), a drug delivery vehicle, were used as the matrix for targeted delivery of peroxide-sensitive chemiluminescent compounds to the epidermis. Luminol and oxalate were chosen as the chemiluminescent test systems, and a formulation was determined based upon non-toxic components, lotion-like properties, and longevity / visibility of a chemiluminescent signal. The luminescence lifetime was extended in the lipid formulation in comparison to the chemiluminescent system in solution. When applied to porcine skin, our formulation remained detectable relative to negative and positive controls. Initial MTT toxicity testing using HepG2 cells have indicated that this formulation is relatively non-toxic. This formulation could be used to image native peroxides present in tissue that may be indicative of skin disease. | en_US |
dc.description.sponsorship | This work was supported by internal research and development (IRAD) funding by the Science and Technology Business Area of the Johns Hopkins University Applied Physics Laboratory. We would like to acknowledge Dr. Victor McCrary, the Business Area Executive for Science and Technology for his support of this project. We would also like to thank Mike Rooney, Jill La Favors, and Neil Murphy for their analytical support. | en_US |
dc.description.uri | https://www.spiedigitallibrary.org/conference-proceedings-of-spie/7397/73970L/Chemiluminescent-solid-lipid-nanoparticles-SLN-and-interations-with-intact-skin/10.1117/12.826397.full?SSO=1 | en_US |
dc.format.extent | 11 pages | en_US |
dc.genre | journal articles | en_US |
dc.identifier | doi:10.13016/m2q5jk-z7s9 | |
dc.identifier.citation | Jennifer Breidenich, Jennifer Breidenich, Julia Patrone, Julia Patrone, Lisa Kelly, Lisa Kelly, Jason Benkoski, Jason Benkoski, Huong Le, Huong Le, Jennifer Sample, Jennifer Sample, "Chemiluminescent solid lipid nanoparticles (SLN) and interations with intact skin", Proc. SPIE 7397, Biosensing II, 73970L (24 August 2009); doi: 10.1117/12.826397; | en_US |
dc.identifier.uri | https://doi.org/10.1117/12.826397 | |
dc.identifier.uri | http://hdl.handle.net/11603/12708 | |
dc.language.iso | en_US | en_US |
dc.publisher | SPIE | en_US |
dc.relation.isAvailableAt | The University of Maryland, Baltimore County (UMBC) | |
dc.relation.ispartof | UMBC Chemistry & Biochemistry Department Collection | |
dc.rights | This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author. | |
dc.rights | One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. | |
dc.subject | chemiluminescent | en_US |
dc.subject | nanoparticles | en_US |
dc.subject | intact skin | en_US |
dc.title | Chemiluminescent solid lipid nanoparticles (SLN) and interations with intact skin | en_US |
dc.type | Text | en_US |