Phylogenetic Analysis of L4-Mediated Autogenous Control of the S10 Ribosomal Protein Operon

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dc.contributor.authorAllen, Todd
dc.contributor.authorShen, Ping
dc.contributor.authorSamsel, Leigh
dc.contributor.authorLiu, Raymond
dc.contributor.authorLindahl, Lasse
dc.contributor.authorZengel, Janice M.
dc.date.accessioned2019-06-11T16:16:14Z
dc.date.available2019-06-11T16:16:14Z
dc.date.issued1999-07-25
dc.description.abstractWe investigated the regulation of the S10 ribosomal protein (r-protein) operon among members of the gamma subdivision of the proteobacteria, which includes Escherichia coli. In E. coli, this 11-gene operon is autogenously controlled by r-protein L4. This regulation requires specific determinants within the untranslated leader of the mRNA. Secondary structure analysis of the S10 leaders of five enterobacteria (Salmonella typhimurium, Citrobacter freundii, Yersinia enterocolitica, Serratia marcescens, and Morganella morganii) and two nonenteric members of the gamma subdivision (Haemophilus influenzae and Vibrio cholerae) shows that these foreign leaders share significant structural homology with the E. coli leader, particularly in the region which is critical for L4-mediated autogenous control in E. coli. Moreover, these heterologous leaders produce a regulatory response to L4 oversynthesis in E. coli. Our results suggest that an E. coli-like L4-mediated regulatory mechanism may operate in all of these species. However, the mechanism is not universally conserved among the gamma subdivision members, since at least one, Pseudomonas aeruginosa, does not contain the required S10 leader features, and its leader cannot provide the signals for regulation by L4 in E. coli. We speculate that L4-mediated autogenous control developed during the evolution of the gamma branch of proteobacteria.en_US
dc.description.sponsorshipThis work was supported by grants AI-15286 and GM-54876 from the National Institutes of Health.en_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC103642/en_US
dc.format.extent9 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2hgbg-leyn
dc.identifier.citationTodd Allen, et.al, Phylogenetic Analysis of L4-Mediated Autogenous Control of the S10 Ribosomal Protein Operon, J Bacteriol. 1999 Oct; 181(19): 6124–6132., https://www.ncbi.nlm.nih.gov/pmc/articles/PMC103642/en_US
dc.identifier.urihttp://hdl.handle.net/11603/14041
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsNon-commercial use only
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectribosomal proteinen_US
dc.subjectEscherichia colien_US
dc.subjectproteobacteriaen_US
dc.subjectenterobacteriaen_US
dc.titlePhylogenetic Analysis of L4-Mediated Autogenous Control of the S10 Ribosomal Protein Operonen_US
dc.typeTexten_US

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