The Interaction of Calcium and Metabolic Oscillations in Pancreatic β-cells

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dc.contributor.authorAronne, Mary
dc.contributor.authorClapp, Samantha
dc.contributor.authorJung, Soohwan
dc.contributor.authorKramer, Abigail
dc.contributor.authorWang, William
dc.contributor.authorPatwardhan, Janita
dc.contributor.authorPeercy, Bradford E.
dc.contributor.authorSherman, Arthur
dc.date.accessioned2018-09-20T18:49:28Z
dc.date.available2018-09-20T18:49:28Z
dc.date.issued2016
dc.description.abstractDiabetes is a disease characterized by an excessive level of glucose in the blood-stream, which may be a result of improper insulin secretion. Insulin is secreted in a bursting behavior of pancreatic β-cells in the islets of Langerhans, which is affected by oscillations of cytosolic calcium concentration. We used the Dual Oscillator Model to explore the role of calcium in calcium oscillation independent and calcium oscillation dependent (CaD) modes as well as the synchronization of metabolic oscillations in electrically coupled β-cells. We also implemented a synchronization index in order to better measure the synchronization of the β-cells within an islet. We observed that voltage or calcium coupling result in increased synchronization and are more effective in CaD modes. Furthermore, we studied heterogeneous modes of coupled β-cells, their arrangements in the islets, and their synchronization. We saw that increasing calcium coupling or increasing voltage coupling in heterogeneous cases increases synchronization; however, in certain cases increasing both voltage and calcium coupling causes desynchronization, primarily in voltage. To better represent an entire islet, we altered previous code by further optimizing run-time and memory usage to allow for a greater number of cells to be simulated for a longer period of time.en_US
dc.description.urihttps://userpages.umbc.edu/~gobbert/papers/REU2016Team4.pdfen_US
dc.format.extent20 pagesen_US
dc.genretechnical reporten_US
dc.identifierdoi:10.13016/M2RB6W582
dc.identifier.urihttp://hdl.handle.net/11603/11332
dc.language.isoen_USen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Mathematics Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Student Collection
dc.relation.ispartofseriesHPCF Technical Report;HPCF-2016-14
dc.rightsThis item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please contact the author.
dc.subjectpancreatic β-cellsen_US
dc.subjectisleten_US
dc.subjectcalciumen_US
dc.subjectmetabolic oscillationsen_US
dc.subjectDual Oscillator Modelen_US
dc.subjectSynchronization Indexen_US
dc.subjectUMBC High Performance Computing Facility (HPCF)en_US
dc.titleThe Interaction of Calcium and Metabolic Oscillations in Pancreatic β-cellsen_US
dc.typeTexten_US

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