Developing the Coupling of the Mechanical to the Electrical and Calcium Systems in a Heart Cell
| dc.contributor.author | Deetz, Kristen | |
| dc.contributor.author | Foster, Nygel | |
| dc.contributor.author | Leftwich, Darius | |
| dc.contributor.author | Meyer, Chad | |
| dc.contributor.author | Patel, Shalin | |
| dc.contributor.author | Barajas, Carlos | |
| dc.contributor.author | Gobbert, Matthias K. | |
| dc.date.accessioned | 2018-09-18T17:55:46Z | |
| dc.date.available | 2018-09-18T17:55:46Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | As the leading cause of death in the United States, heart disease has become a principal concern in modern society. Cardiac arrhythmias can be caused by a dysregulation of calcium dynamics in cardiomyocytes. Calcium dysregulation, however, is not yet fully understood and is not easily predicted; this provides motivation for the subsequent research. Excitation-contraction coupling (ECC) is the process through which cardiomyocytes undergo contraction from an action potential. Calcium induced calcium release (CICR) is the mechanism through which electrical excitation is coupled with mechanical contraction through calcium signaling. The study of the interplay between electrical excitation, calcium signaling, and mechanical contraction has the potential to better our understanding of the regular functioning of the cardiomyocytes and help us understand how any dysregulation can lead to potential cardiac arrhythmias. ECC, of which CICR is an important part, can be modeled using a system of partial differential equations that link the electrical excitation, calcium signaling, and mechanical contraction components of a cardiomyocyte. We extend a previous model to implement a seven variable model that includes for the first time the mechanical component of the ECC. We conduct a parameter study to determine how the interaction of electrical and calcium systems can impact the cardiomyocyte’s levels of contraction. | en_US |
| dc.description.sponsorship | These results were obtained as part of the REU Site: Interdisciplinary Program in High Performance Computing (hpcreu.umbc.edu) in the Department of Mathematics and Statistics at the University of Maryland, Baltimore County (UMBC) in Summer 2017. This program is funded by the National Science Foundation (NSF), the National Security Agency (NSA), and the Department of Defense (DOD), with additional support from UMBC, the Department of Mathematics and Statistics, the Center for Interdisciplinary Research and Consulting (CIRC), and the UMBC High Performance Computing Facility (HPCF). HPCF is supported by the U.S. National Science Foundation through the MRI program (grant nos. CNS–0821258 and CNS–1228778) and the SCREMS program (grant no. DMS–0821311), with additional substantial support from UMBC. Co-authors Nygel Foster, and Darius Leftwich were supported, in part, by the UMBC National Security Agency (NSA) Scholars Program through a contract with the NSA. The team also thanks Wesley Collins for initial help with the cluster maya in HPCF. Graduate assistant Carlos Barajas was supported by UMBC. All of us thank Dr. Brad Peercy for invaluable discussions on the background and goals of mathematical physiology. | en_US |
| dc.description.uri | https://userpages.umbc.edu/~gobbert/papers/REU2017Team5.pdf | en_US |
| dc.format.extent | 44 pages | en_US |
| dc.genre | Technical Report | en_US |
| dc.identifier | doi:10.13016/M26Q1SM4N | |
| dc.identifier.uri | http://hdl.handle.net/11603/11308 | |
| dc.language.iso | en_US | en_US |
| dc.relation.isAvailableAt | The University of Maryland, Baltimore County (UMBC) | |
| dc.relation.ispartof | UMBC Computer Science and Electrical Engineering Department Collection | |
| dc.relation.ispartof | UMBC Faculty Collection | |
| dc.relation.ispartof | UMBC Student Collection | |
| dc.relation.ispartof | UMBC Mathematics and Statistics Department | |
| dc.relation.ispartofseries | HPCF Technical Report HPCF-2017-15; | |
| dc.rights | This item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please contact the author. | |
| dc.subject | Heart disease | en_US |
| dc.subject | Heart cell | en_US |
| dc.subject | Cardiac arrhythmia | en_US |
| dc.subject | Excitation-contraction coupling | en_US |
| dc.subject | Calcium Induced Calcium Release | en_US |
| dc.subject | UMBC High Performance Computing Facility (HPCF) | en_US |
| dc.title | Developing the Coupling of the Mechanical to the Electrical and Calcium Systems in a Heart Cell | en_US |
| dc.type | Text | en_US |