Transcriptional control of the S10 ribosomal protein operon of Escherichia coli after a shift to higher temperature

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dc.contributor.authorZengel, J. M.
dc.contributor.authorLindahl, L.
dc.date.accessioned2019-06-05T16:51:31Z
dc.date.available2019-06-05T16:51:31Z
dc.date.issued1985-07
dc.description.abstractIn the 5 to 10 min immediately following a shift from 30 to 42 degrees C, the differential synthesis rates of ribosomal proteins encoded by the 11-gene S10 operon are transiently decreased. This effect results largely from a two- to threefold decrease in the differential rate of transcription of the operon. The inhibition of mRNA synthesis is apparently due to two types of control: (i) initiation of transcription at the S10 promoter is inhibited and (ii) readthrough at the attenuator in the S10 leader is decreased. Both of these effects on transcription are independent of the heat shock regulatory gene, htpR. Furthermore, the inhibition of transcription is observed in both relA+ and relA cells, suggesting that the temperature-induced repression does not require the relA-dependent accumulation of guanosine tetraphosphate (ppGpp). However, recovery from the heat shock was slower in relA+ strains than in relA strains. None of the other ribosomal protein operons that we analyzed showed such a strong decrease in transcription after the heat shock.en_US
dc.description.sponsorshipThis work was supported by a research grant and a Research Career Development Award (to L.L.) from the National Institute of Allergy and Infectious Diseases.en_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC219091/en_US
dc.format.extent8 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2vpwp-io0h
dc.identifier.citationJ M Zengel and L Lindahl, Transcriptional control of the S10 ribosomal protein operon of Escherichia coli after a shift to higher temperature, J Bacteriol. 1985 Jul; 163(1): 140–147, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC219091/en_US
dc.identifier.urihttp://hdl.handle.net/11603/14015
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjectS10 ribosomal proteinen_US
dc.subjectEscherichia colien_US
dc.subjectguanosine tetraphosphate (ppGpp)en_US
dc.titleTranscriptional control of the S10 ribosomal protein operon of Escherichia coli after a shift to higher temperatureen_US
dc.typeTexten_US

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