Wastewater-based epidemiology in Beijing, China: Prevalence of antibiotic use in flu season and association of pharmaceuticals and personal care products with socioeconomic characteristics

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dc.contributor.authorZhang, Yizhe
dc.contributor.authorDuan, Lei
dc.contributor.authorWang, Bin
dc.contributor.authorDu, Yulin
dc.contributor.authorCagnetta, Giovanni
dc.contributor.authorHuang, Jun
dc.contributor.authorBlaney, Lee
dc.contributor.authorYu, Gang
dc.date.accessioned2019-05-24T17:26:00Z
dc.date.available2019-05-24T17:26:00Z
dc.date.issued2019-04
dc.description.abstractWastewater-based epidemiology is an emerging field that has mostly been applied to investigate consumption of illicit drugs. In this study, the wastewater-based epidemiology approach was employed to study consumption of pharmaceuticals and personal care products (PPCPs) and measure their prevalence of use in eight densely populated, urban areas of Beijing, China. Ammonium loads were used to estimate the population equivalents of each sewershed. These estimates were applied to calculate population-normalized antibiotic consumption and prevalence of use during flu season, when antibiotics are frequently misused as a medical treatment. Results indicated that 21.9 g d−1 (10⁴ people)⁻¹ of ten popular antibiotics were consumed across the eight sewersheds, indicating that 1.98‰ of the 12.5 million population equivalents used these antibiotics during the sampling period. A comparison of these results to calculations made using previously reported data from 2013 suggest that recent Chinese antibiotic control policies have been effective. Uncertainty analyses were conducted to identify the 95% confidence range for antibiotic prevalence of use as 1.44–3.61‰. Human excretion factors were identified as the most sensitive variable. The wastewater-based epidemiology methods were also applied to a wider range of PPCPs, and the results indicated positive relationships between consumption and socioeconomic factors, such as housing price and population density. Overall, this work provides important public health information on antibiotic use and elucidates relationships between PPCP consumption and socioeconomic characteristics.en_US
dc.description.sponsorshipThis work was supported by the National Natural ScienceFoundation of China [grant number 21577075], Major Science andTechnology Program for Water Pollution Control and Treatment inChina [grant number 2017ZX07202006], and Program for ChangjiangScholars and Innovative Research Team in University [grant numberIRT1261].en_US
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S0160412018320877#!en_US
dc.format.extent9 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2ermp-zsse
dc.identifier.citationYizhe Zhang, et.al, Wastewater-based epidemiology in Beijing, China: Prevalence of antibiotic use in flu season and association of pharmaceuticals and personal care products with socioeconomic characteristics, Environment International Volume 125, April 2019, Pages 152-160, https://doi.org/10.1016/j.envint.2019.01.061en_US
dc.identifier.urihttps://doi.org/10.1016/j.envint.2019.01.061
dc.identifier.urihttp://hdl.handle.net/11603/13946
dc.language.isoen_USen_US
dc.publisherElsevier Ltden_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemical, Biochemical & Environmental Engineering Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPPCPsen_US
dc.subjectAntibioticsen_US
dc.subjectprevalence of useen_US
dc.subjectuncertainty analysisen_US
dc.subjectwastewater-based epidemiologyen_US
dc.subjectsocioeconomicsen_US
dc.titleWastewater-based epidemiology in Beijing, China: Prevalence of antibiotic use in flu season and association of pharmaceuticals and personal care products with socioeconomic characteristicsen_US
dc.typeTexten_US

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