Chemiluminescent solid lipid nanoparticles (SLN) and interations with intact skin

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https://www.spiedigitallibrary.org/conference-proceedings-of-spie/7397/73970L/Chemiluminescent-solid-lipid-nanoparticles-SLN-and-interations-with-intact-skin/10.1117/12.826397.full?SSO=1

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https://doi.org/10.1117/12.826397
 http://hdl.handle.net/11603/12708

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UMBC Chemistry & Biochemistry Department

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Date

2009-08-24

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journal articles
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Citation of Original Publication

Jennifer Breidenich, Jennifer Breidenich, Julia Patrone, Julia Patrone, Lisa Kelly, Lisa Kelly, Jason Benkoski, Jason Benkoski, Huong Le, Huong Le, Jennifer Sample, Jennifer Sample, "Chemiluminescent solid lipid nanoparticles (SLN) and interations with intact skin", Proc. SPIE 7397, Biosensing II, 73970L (24 August 2009); doi: 10.1117/12.826397;

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Subjects

chemiluminescent
nanoparticles
intact skin

Abstract

We report the synthesis and characterization of a novel nanoparticle formulation designed for skin penetration for the purpose of skin imaging. Solid lipid nanoparticles (SLNs), a drug delivery vehicle, were used as the matrix for targeted delivery of peroxide-sensitive chemiluminescent compounds to the epidermis. Luminol and oxalate were chosen as the chemiluminescent test systems, and a formulation was determined based upon non-toxic components, lotion-like properties, and longevity / visibility of a chemiluminescent signal. The luminescence lifetime was extended in the lipid formulation in comparison to the chemiluminescent system in solution. When applied to porcine skin, our formulation remained detectable relative to negative and positive controls. Initial MTT toxicity testing using HepG2 cells have indicated that this formulation is relatively non-toxic. This formulation could be used to image native peroxides present in tissue that may be indicative of skin disease.