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dc.contributor.advisorErwin-Cohen, Rebecca
dc.contributor.advisorKapnick, Senta
dc.contributor.advisorLaufer, Craig
dc.contributor.authorThang, Esther
dc.contributor.departmentHood College Biomedical and Environmentalen_US
dc.contributor.programHood College Biomedical Scienceen_US
dc.date.accessioned2019-08-09T14:39:15Z
dc.date.available2019-08-09T14:39:15Z
dc.date.issued2019-08-09
dc.description.abstractNeutrophils serve a vital role in innate immune defense against bacterial and fungal pathogens. While neutrophils function in the most robust immune defense, they can also play a detrimental role in inflammatory conditions that can even lead to death. Reduction of complement factor 5a receptor-1 (C5aR1) suppresses neutrophils to get signals to migrate to the affected site, thus reducing inflammation. Previous research conducted by Miettinen et al. in 2018 demonstrated that 67-82% of mouse neutrophil C5aR1 protein was knocked down by siRNA and antisense oligonucleotides (ASO) using CD177-mediated hybrid polymerized liposome nanoparticles (HPLN). Approximately 30% of HPLNs were degraded in the endosome. In this proposal, I will incorporate a pH sensitive Glutamic acid-Alanine-Leucine-Alanine (GALA) peptide on the surface of HPLN, which will help the HPLN escape the endosome. I hypothesize this will completely and transiently knock down neutrophil C5aR1.en_US
dc.format.extent54 pagesen_US
dc.genreMock Grant Proposalen_US
dc.identifierdoi:10.13016/m2ctcp-hata
dc.identifier.urihttp://hdl.handle.net/11603/14414
dc.language.isoen_USen_US
dc.relation.isAvailableAtHood College
dc.titleTHE REDUCTION OF NEUTROPHIL POPULATIONS IN INFLAMMATORY CONDITIONS USING CD177-MEDIATED PH-SENSITIVE FUSOGENIC NANOPARTICLESen_US
dc.typeTexten_US


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