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Adaptive Properties of the Genetically Encoded Amino Acid Alphabet Are Inherited from Its Subsets
Life uses a common set of 20 coded amino acids (CAAs) to construct proteins. This set was likely canonicalized during early evolution; before this, smaller amino acid sets were gradually expanded as new synthetic, proofreading ...
Evolution as a Guide to Designing xeno Amino Acid Alphabets
Here, we summarize a line of remarkably simple, theoretical research to better understand the chemical logic by which life’s standard alphabet of 20 genetically encoded amino acids evolved. The connection to the theme of ...