Optimizing tPA Therapy for Stroke Victims

Thumbnail Image

Files

ChatainOscarLouisJean_Fall2018.pdf (4.69 MB)

Links to Files

Permanent Link

http://hdl.handle.net/11603/17441

Collections

SU Honors College Theses

Author/Creator

Author/Creator ORCID

Date

2018

Type of Work

theses
Text

Department

Chemistry

Program

Citation of Original Publication

Rights

Subjects

Transient ischemic attack
Clinical medicine
Theraputics

Abstract

Tissue Plasminogen Activator (tPA) remains one of the most effective thrombolytic agents given to patients that present with acute ischemic strokes. However, increased chances of brain hemorrhaging are observed if administered outside of the accepted time window of 4.5 hours. Patients who already have prior trauma comorbidities are at the highest risk and are therefore not eligible for reperfusion therapy using tPA. In this manuscript, the author aims to assess the feasibility of counteracting tPA mediated blood brain barrier (BBB) degradation and proposes novel diagnostic techniques to quantify the efficacy of potential adjuvant therapies reported in the literature.