Microfibrous extracellular matrix enhances in vitro modeling of the liver hepatocytes by modulating metabolism and integrin expression
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Date
2020-01
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Citation of Original Publication
Tianjiao Huang, Curtis G. Jones, Jay H. Chung, and Chengpeng Chen, Microfibrous Extracellular Matrix Changes the Liver Hepatocyte Energy Metabolism via Integrins, ACS Biomaterials Science & Engineering 2020 6 (10), 5849-5856 DOI: 10.1021/acsbiomaterials.0c01311
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This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in ACS Biomater. Sci. Eng, copyright © American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acsbiomaterials.0c01311.
This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in ACS Biomater. Sci. Eng, copyright © American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acsbiomaterials.0c01311.
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Abstract
2 Introduction The liver carries out a number of essential functions, including blood detoxification, protein synthesis, regulation of energy balance, and production of other biochemicals to maintain the whole-body homeostasis1. In addition to these physiological functions, the liver is also the main site of drug metabolism, making it vulnerable to drug toxicity; indeed, hepatotoxicity is one of the leading causes for drug failure2. Thus, detecting the potential for hepatotoxicity of a drug at the early stage of drug development/screening will minimize the failure rate and, therefore, the cost of bringing a drug into the market. Therefore, hepatic models are invaluable tools in drug discovery and development