Induction of the SOS response by bacteriophage lytic development in Salmonella enterica

Author/Creator ORCID

Date

2006-05-19

Department

Program

Citation of Original Publication

Susana Campoy, Anna Hervàs, Núria Busquets, Ivan Erill, Laura Teixidó, Jordi Barbé, Induction of the SOS response by bacteriophage lytic development in Salmonella enterica, Virology, Volume 351, Issue 2, 2006, Pages 360-367,https://doi.org/10.1016/j.virol.2006.04.001.

Rights

This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.

Abstract

Infection of Salmonella enterica with lytic mutants of either P22 or SE1 bacteriophages triggers the expression of its DNA damage-inducible SOS response through a lexA-dependent pathway. This induction of the SOS system strictly requires the presence of the bacteriophage kil gene. Accordingly, plasmid overexpression of the kil gene also promotes the S. enterica SOS network induction. Furthermore, S. enterica Gifsy prophages are induced following the infection with SE1 and P22 lytic derivatives. The observed data reveal a hitherto unknown SOS system-mediated fail-safe mechanism of resident prophages against infection with heteroimmune lytic bacteriophages and suggest a novel role for the kil family of proteins.