A SiC microdevice for the minimally invasive monitoring of ischemia in living tissues

Author/Creator ORCID

Date

2006-03

Department

Program

Citation of Original Publication

Gómez, R., Ivorra, A., Villa, R. et al. A SiC microdevice for the minimally invasive monitoring of ischemia in living tissues. Biomed Microdevices 8, 43–49 (2006). https://doi.org/10.1007/s10544-006-6381-y

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This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
This is a pre-print of an article published in Biomedical Microdevices. The final authenticated version is available online at: https://doi.org/10.1007/s10544-006-6381-y.

Subjects

Abstract

Monitoring of ischemia in living tissues is a field of increasing interest in many clinical settings. In this work we report for the first time anywhere the development of needle-shaped, minimally-invasive impedance probes based on silicon carbide (SiC) substrates. An in-vitro comparison of these new devices with Si-based impedance probes demonstrates that their effective operation range extends up to the 100 kHz range, thus allowing a wide-spectrum multi-frequency analysis of impedance modulus and phase angle. Furthermore, we show that, when applied to in-vivo settings, this kind of analysis yields to an accurate monitoring of ischemia, while making possible the application of more robust mathematical methods for the study of impedance in living tissues.