Accessory olfactory bulb function is modulated by input from the main olfactory epithelium
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Date
2010-03-16
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Slotnick et al., Accessory olfactory bulb function is modulated by input from the main olfactory epithelium, Eur J Neurosci. 2010 March ; 31(6): 1108–1116. doi:10.1111/j.1460-9568.2010.07141.x
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This is the peer reviewed version of the following article: Slotnick et al., Accessory olfactory bulb function is modulated by input from the main olfactory epithelium, Eur J Neurosci. 2010 March ; 31(6): 1108–1116. doi:10.1111/j.1460-9568.2010.07141.x, which has been published in final form at https://doi.org/10.1111/j.1460-9568.2010.07141.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
This is the peer reviewed version of the following article: Slotnick et al., Accessory olfactory bulb function is modulated by input from the main olfactory epithelium, Eur J Neurosci. 2010 March ; 31(6): 1108–1116. doi:10.1111/j.1460-9568.2010.07141.x, which has been published in final form at https://doi.org/10.1111/j.1460-9568.2010.07141.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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Abstract
Although it is now established that sensory neurons in both the main olfactory epithelium and the vomeronasal organ may be activated by both general and pheromonal odorants, it remains unclear what initiates sampling by the vomeronasal organ. Anterograde transport of wheat germ agglutinin–horseradish peroxidase was used to determine that adequate intranasal syringing with zinc sulfate interrupted all inputs to the main olfactory bulb but left intact those to the accessory olfactory bulb. Adult male treated mice were frankly anosmic when tested with pheromonal and non‐pheromonal odors and failed to engage in aggressive behavior. Treated juvenile females failed to show puberty acceleration subsequent to exposure to bedding from adult males. Activation of the immediate early gene c‐Fos and electrovomeronasogram recording confirmed the integrity of the vomeronasal system in zinc sulfate‐treated mice. These results support the hypothesis that odor detection by the main olfactory epithelium is required to initiate sampling by the vomeronasal system.