Comparison of the Old and New - Novel Mechanisms of Action for Anti-coronavirus Nucleoside Analogues
Loading...
Links to Files
Author/Creator
Author/Creator ORCID
Date
2022-05-25
Type of Work
Department
Program
Citation of Original Publication
Thames, Joy E., and Katherine L. Seley-Radtke. 2022. “Comparison of the Old and New - Novel Mechanisms of Action for Anti-Coronavirus Nucleoside Analogues”. CHIMIA 76 (5):409-17. https://doi.org/10.2533/chimia.2022.409.
Rights
This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
Attribution 4.0 International (CC BY 4.0)
Attribution 4.0 International (CC BY 4.0)
Subjects
Abstract
Over the past two and a half years the world has seen a desperate scramble to find a treatment for SARS-CoV-2 and COVID. In that regard, nucleosides have long served as the cornerstone to antiviral treatments due to their resemblance to the naturally occurring nucleosides that are involved in numerous biological processes. Unlike other viruses however, it was found early on during the search for drugs to treat SARS-1 and later MERS, that the coronaviruses possess a unique repair enzyme, an exonuclease (ExoN)[3] which rendered nucleoside analogues useless, thus negating their use.[4] During the current outbreak however, as both well-known and new nucleoside analogues were investigated or reinvestigated as a possible cure for SARS-CoV-2, several novel and/or lesser-known mechanisms of action were uncovered. This review briefly describes these mechanisms.