Preliminary Validation of a New Measure of Duration of Untreated psychosis: The SIPS-DUP

Author/Creator

Author/Creator ORCID

Date

2021-01-01

Department

Psychology

Program

Psychology

Citation of Original Publication

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Abstract

A growing body of research suggests that, for those who develop a psychotic illness, early detection of symptoms and initiation of treatment is associated with improved clinical and functional outcomes, as well as reductions of positive symptoms (experiences that are in excess of otherwise typical functioning, and include hallucinations, delusions, and/or disorganized behavior) and intensive service use (e.g., emergency room and inpatient hospitalization). Early intervention is also cost effective and instills a more positive and helpful impression of the mental health system (Lucksted et al., 2015). In studies exploring both immediate and distal effects of the first episode of psychosis, researchers have found that the duration of untreated psychosis (DUP), the time between the emergence of psychotic symptoms and adequate treatment, may impact illness course and treatment response (Kane et al., 2016). Although there are several instruments frequently used to measure DUP in people within their first episode of psychosis, these are primarily derived from approaches that consider fully manifested psychosis as the point of reference at which evaluation should be initiated. Given the possibility of identifying psychosis risk prior to full threshold symptoms, and the benefits of a short DUP, there is compelling rationale to improve upon measurement strategies of DUP. The current study evaluated the validity of a new tool designed to assess DUP based on a modified version of the Structured Interview for Psychosis-risk Syndromes (SIPS), the gold-standard interview for assessing risk for psychosis. Consistent with other measures of DUP, the new measure was associated with various positive and negative symptoms of psychosis, indicating some preliminary construct validity for the tool. This initial psychometric validation provides support for a measure that possesses methodological advantages relative to existing tools of DUP measurement.