Now showing items 1-2 of 2
A MAJORITY OF CLONALLY-EXPANDED T CELLS CONTAINING REPLICATION-COMPETENT HIV-1 PROVIRUSES ARE TRANSCRIPTIONALLY SILENT
Current antiretroviral therapy (ART) is highly effective at blocking HIV-1 replication but does not cure the infection due to the persistence of latently-infected cells that are able to undergo cellular proliferation (1). ...
IDENTICAL HIV-1 PROVIRUSES ORIGINATE FROM CELL PROLIFERATION OR INFECTION WITH A COMMON VIRAL ANCESTOR
Understanding the mechanisms for HIV-1 persistence during antiretroviral therapy (ART) is crucial for developing curative strategies. Due to the high intra-patient genetic diversity of HIV-1, I hypothesized that integrated ...