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A MAJORITY OF CLONALLY-EXPANDED T CELLS CONTAINING REPLICATION-COMPETENT HIV-1 PROVIRUSES ARE TRANSCRIPTIONALLY SILENT
Current antiretroviral therapy (ART) is highly effective at blocking HIV-1 replication but does not cure the infection due to the persistence of latently-infected cells that are able to undergo cellular proliferation (1). ...
IDENTICAL HIV-1 PROVIRUSES ORIGINATE FROM CELL PROLIFERATION OR INFECTION WITH A COMMON VIRAL ANCESTOR
Understanding the mechanisms for HIV-1 persistence during antiretroviral therapy (ART) is crucial for developing curative strategies. Due to the high intra-patient genetic diversity of HIV-1, I hypothesized that integrated ...
CHARACTERIZATION OF THE HIV-1 PROVIRAL LANDSCAPE IN PERINATALLY INFECTED EARLY TREATED CHILDREN ON LONG-TERM ANTIRETROVIRAL THERAPY
Antiretroviral therapy (ART) prevents disease progression in people living with Human Immunodeficiency Virus (HIV) (PLWH). However, off-target effects can result in liver disease, heart disease, diabetes, and more, and ...