This project proposes to demonstrate the overexpression of the selected tyrosine kinase receptor, RTK, (AXL, HER2, and PDGFRβ) and their participation in oncogenic KRAS driven pancreatic cancer in vitro. The experimental ...

While the baculovirus expression vector system (BEVS) has proved its ability to produce high quality recombinant proteins utilizing a eukaryotic host, limited improvements have been made with regards to expressing multiple ...

Up to 30% of cancers harbor mutations in the small GTPase RAS that maintain the protein in an active conformation and drive uncontrolled cellular proliferation, promote cell survival, and alter cellular metabolism, movement, ...