Now showing items 1-3 of 3
STUDIES OF AXL, HER2, AND PDGFRβ RECEPTOR TYROSINE KINASES IN MUTANT KRAS-DRIVEN PANCREATIC CANCER IN VITRO
This project proposes to demonstrate the overexpression of the selected tyrosine kinase receptor, RTK, (AXL, HER2, and PDGFRβ) and their participation in oncogenic KRAS driven pancreatic cancer in vitro. The experimental ...
EVALUATING MODIFIED POLYHEDRIN PROMOTERS FOR IMPROVED CO-EXPRESSION OF KRAS4b
While the baculovirus expression vector system (BEVS) has proved its ability to produce high quality recombinant proteins utilizing a eukaryotic host, limited improvements have been made with regards to expressing multiple ...
Characterization of effector binding preferences between oncogenic mutants KRAS4b G12D and KRAS4b G12C
Up to 30% of cancers harbor mutations in the small GTPase RAS that maintain the protein in an active conformation and drive uncontrolled cellular proliferation, promote cell survival, and alter cellular metabolism, movement, ...