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Utilizing Ayurvedic literature for the identification of novel phytochemical inhibitors of botulinum neurotoxin A
(Journal of Ethnopharmacology, 2017-02-02)
Ethnopharmacological relevance Ayurveda, an ancient holistic system of health care practiced on the Indian subcontinent, utilizes a number of multi-plant formulations and is considered by many as a potential source for ...
A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A
(Bioorganic & Medicinal Chemistry Letters, 2017-02-01)
Our initial discovery of 8-hydroxyquinoline inhibitors of BoNT/A and separation/testing of enantiomers of one of the more active leads indicated considerable flexibility in the binding site. We designed a limited study to ...