Now showing items 1-2 of 2
Methamphetamine-Induced Short-Term Increase and Long-Term Decrease in Spatial Working Memory Affects Protein Kinase M Zeta (PKMζ), Dopamine, and Glutamate Receptors
(Frontiers in Behavioral Neuroscience, 2014-12-18)
Methamphetamine (MA) is a toxic, addictive drug shown to modulate learning and memory, yet the neural mechanisms are not fully understood. We investigated the effects of 2 weekly injections of MA (30 mg/kg) on working ...
A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A
(Bioorganic & Medicinal Chemistry Letters, 2017-02-01)
Our initial discovery of 8-hydroxyquinoline inhibitors of BoNT/A and separation/testing of enantiomers of one of the more active leads indicated considerable flexibility in the binding site. We designed a limited study to ...