Browsing Stevenson University Faculty and Staff Works by Author "Cardellina, John H. II"

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A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A

Harrell, William A. Jr.; Vieira, Rebecca C.; Ensel, Susan M.; Montgomery, Vicki; Guernieri, Rebecca; Eccard, Vanessa S.; Campbell, Yvette; Roxas-Duncan, Virginia; Cardellina, John H. II; Webb, Robert P.; Smith, Leonard A. (Bioorganic & Medicinal Chemistry Letters, 2017-02-01)

Our initial discovery of 8-hydroxyquinoline inhibitors of BoNT/A and separation/testing of enantiomers of one of the more active leads indicated considerable flexibility in the binding site. We designed a limited study to ...