Now showing items 117-118 of 118

    • Yap suppresses T-cell function and infiltration in the tumor microenvironment 

      Stampouloglou, Eleni; Cheng, Nan; Federico, Anthony; Slaby, Emily; Monti, Stefano; Szeto, Gregory L.; Varelas, Xaralabos (PLOS, 2020-01-13)
      A major challenge for cancer immunotherapy is sustaining T-cell activation and recruitment in immunosuppressive solid tumors. Here, we report that the levels of the Hippo pathway effector Yes-associated protein (Yap) are ...
    • β1-Integrin cytoskeletal signaling regulates sensory neuron response to matrix dimensionality 

      Ribeiro, Andreia; Balasubmramanian, Swarnalatha; Hughes, Dalton; Vargo, Shelby; Powell, Elizabeth M.; Leach, Jennie B. (Elsevier B.V, 2013-09-17)
      Neuronal differentiation, pathfinding and morphology are directed by biochemical cues that in vivo are presented in a complex scaffold of extracellular matrix (ECM). This microenvironment is three-dimensional (3D) and ...