Browsing UMBC Chemical, Biochemical & Environmental Engineering Department by Issue Date
Now showing items 1-20 of 239
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Rheological Characterization and Biological and Mass Transfer Kinetics of Cellulase-Producing T. reesei Viscous Suspensions
(1995)Steady and dynamic shear measurements are utilized to characterize the rheological behavior of Trichoderma reesi RUT-C30 fungal suspensions during batch growth on xylose (soluble substrate) or cellulose (particulate solid ... -
Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells
(PNAS, 2002-03-05)To better direct repair following spinal cord injury (SCI), we designed an implant modeled after the intact spinal cord consisting of a multicomponent polymer scaffold seeded with neural stem cells. Implantation of the ... -
Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds
(PNAS, 2003-10-28)Human embryonic stem (hES) cells hold promise as an unlimited source of cells for transplantation therapies. However, control of their proliferation and differentiation into complex, viable 3D tissues is challenging. Here ... -
Tissue engineering: current state and perspectives
(Springer Nature, 2004-02-20)Tissue engineering is an interdisciplinary field that involves cell biology, materials science, reactor engineering, and clinical research with the goal of creating new tissues and organs. Significant advances in tissue ... -
Assessment of Elasticity and Topography of Aspergillus nidulans Spores via Atomic Force Microscopy
(American Society for Microbiology, 2004-09-27)Previous studies have described both surface morphology and adhesive properties of fungal spores, but little information is currently available on their mechanical properties. In this study, atomic force microscopy (AFM) ... -
Proteome Analysis to Assess Physiological Changes in Escherichia coli Grown Under Glucose-Limited Fed-Batch Conditions
(Wiley Periodicals, 2005-09-22)Proteome analysis was used to compare global protein expression changes in Escherichia coli fermentation between exponential and glucose-limited fed-batch phase. Two-dimensional gel electrophoresis and MALDI-TOF mass ... -
A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks invivo
(PNAS, 2006-02-21)A microvascular network is critical for the survival and function of most tissues. We have investigated the potential of neural progenitor cells to augment the formation and stabilization of microvascular networks in a ... -
CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo
(Elsevier, 2006-12-20)Delivery of factors capable of promoting oligodendrocyte precursor cell (OPC) survival and differentiation in vivo is an important therapeutic strategy for a variety of pathologies in which demyelination is a component, ... -
The capsule polysaccharide structure and biogenesis for non-O1 Vibrio cholerae NRT36S: genes are embedded in the LPS region
(Originally published by: BMC Microbiology, 2007-03-15)Background: In V. cholerae, the biogenesis of capsule polysaccharide is poorly understood. The elucidation of capsule structure and biogenesis is critical to understanding the evolution of surface polysaccharide and the ... -
Beta Amyloid-Neuron Interactions Explored via Computational Modeling
(2008-08-21)There has been considerable research into the mechanism by which beta amyloid (A?), one of the primary constituents in Alzheimer's disease, causes death in neurons. Many mechanisms have been proposed, and there is no ... -
Application of High Throughput Bioreactors for Subclone Selection
(2008-10-22)The demand for monoclonal antibodies in pharmaceutical drug production requires the highest technology be invested in obtaining a stable, high producing cell line. Currently the most common method of selection is by limiting ... -
Altered structural and mechanical properties in decellularized rabbit carotid arteries
(Elsevier B.V, 2008-12-11)Recently, major achievements in creating decellularized whole tissue scaffolds have drawn considerable attention to decellularization as a promising approach for tissue engineering. Decellularized tissues are expected ... -
Engineering angiogenesis following spinal cord injury: a coculture of neural progenitor and endothelial cells in a degradable polymer implant leads to an increase in vessel density and formation of the blood–spinal cord barrier
(Wiley, 2008-12-22)Angiogenesis precedes recovery following spinal cord injury and its extent correlates with neural regeneration, suggesting that angiogenesis may play a role in repair. An important precondition for studying the role of ... -
Quantitative analysis of the accumulation, architectural organization, detachment and reseeding of Staphylococcus aureus biofilms under physiological fluid shear conditions
(2009-01-01)Staphylococcus aureus is an opportunistic gram- positive pathogen responsible for a wide variety of animal and human infections. In humans, it is associated with both superficial and invasive cases of infections, including ... -
Role of ?- Amyloid Structure and residue accessibility in cell interactions associated with Alzheimer's disease
(2009-01-01)Beta- amyloid peptide ( A?) is the major protein constituent found in senile plaques in Alzheimer’s disease ( AD). A? is able to bind in the cell membrane to a variety of biomolecules, including lipids and protein, but ... -
Microbial nar-GFP cell sensors reveal oxygen limitations in highly agitated and aerated laboratory-scale fermentors
(BioMed Central, 2009-01-15)Background: Small-scale microbial fermentations are often assumed to be homogeneous, and oxygen limitation due to inadequate micromixing is often overlooked as a potential problem. To assess the relative degree of ... -
Serial displacement chromatofocusing and its applications in multidimensional chromatography and gel electrophoresis: I. Theory and general considerations
(Elsevier B.V, 2009-02-06)The technique of “serial displacement chromatofocusing” (SDC) is investigated both theoretically and experimentally with model mixtures of proteins and peptides. The method employs a multistep, retained pH gradient formed ... -
Fluorescent microparticles for sensing cell microenvironment oxygen levels within 3D scaffolds
(Elsevier B.V, 2009-03-14)We present the development and characterization of fluorescent oxygen-sensing microparticles designed for measuring oxygen concentration in microenvironments existing within standard cell culture and transparent three-dimensional ... -
Intravenous Hemostat: Nanotechnology to Halt Bleeding
(AAAS, 2009-12-16)Blood loss is the major cause of death in both civilian and battlefield traumas. Methods to staunch bleeding include pressure dressings and absorbent materials. For example, QuikClot effectively halts bleeding by absorbing ... -
Bridging the divide between neuroprosthetic design, tissue engineering and neurobiology
(Frontiers Media S.A., 2010-02-08)Neuroprosthetic devices have made a major impact in the treatment of a variety of disorders such as paralysis and stroke. However, a major impediment in the advancement of this technology is the challenge of maintaining ...