Now showing items 1-6 of 6

    • Cell deformation cytometry using diode-bar optical stretchers 

      Sraj, Ihab; Eggleton, Charles D.; Jimenez, Ralph; Hoover, Erich E.; Squier, Jeffrey A.; Chichester, Justin; Marr, David W. (Society of Photo-Optical Instrumentation Engineers., 2010-08-04)
      The measurement of cell elastic parameters using optical forces has great potential as a reagent-free method for cell classification, identification of phenotype, and detection of disease; however, the low throughput ...
    • Dynamic ray tracing for modeling optical cell manipulation 

      Sraj, Ihab; Szatmary, Alex C.; Marr, David W. M.; Eggleton, Charles D. (OSA, 2010-07-23)
      Current methods for predicting stress distribution on a cell surface due to optical trapping forces are based on a traditional ray optics scheme for fixed geometries. Cells are typically modeled as solid spheres as this ...
    • Effect of Viscoelasticity on the Analysis of Single-Molecule Force Spectroscopy on Live Cells 

      Gupta, V.K.; Neeves, K.B.; Eggleton, C.D. (Elsevier Inc, 2012-07-03)
      Single-molecule force spectroscopy is used to probe the kinetics of receptor-ligand bonds by applying mechanical forces to an intermediate media on which the molecules reside. When this intermediate media is a live cell, ...
    • Linear diode laser bar optical stretchers for cell deformation 

      Sraj, Ihab; Marr, David W. M.; Eggleton, Charles D. (Optical Society of America, 2010-08-05)
      To investigate the use of linear diode laser bars to optically stretch cells and measure their mechanical properties, we present numerical simulations using the immersed boundary method (IBM) coupled with classic ray optics. ...
    • Multi-scale simulation of L-selectin–PSGL-1-dependent homotypic leukocyte binding and rupture 

      Gupta, V.K.; Sraj, Ihab A.; Konstantopoulos, Konstantinos; Eggleton, Charles D. (Springer-Verlag, 2010-03-14)
      L-selectin–PSGL-1-mediated polymorphonuclear (PMN) leukocyte homotypic interactions potentiate the extent of PMN recruitment to endothelial sites of inflammation. Cell–cell adhesion is a complex phenomenon involving the ...
    • Stress concentration around a rectangular cuboid hole in a three-dimensional elastic body under tension loading 

      Yang, Yi; Cheng, Yufeng; Zhu, Weidong (Springer, 2018-05-29)
      Stress concentration caused by holes can be investigated by numerical and analytical methods. Current analytical methods can only solve two-dimensional problems. This paper proposes an analytical study on a three-dimensional ...