The SOS Response Controls Integron Recombination
dc.contributor.author | Guerin, Émilie | |
dc.contributor.author | Cambray, Guillaume | |
dc.contributor.author | Sanchez-Alberola, Neus | |
dc.contributor.author | Campoy, Susana | |
dc.contributor.author | Erill, Ivan | |
dc.contributor.author | Re, Sandra Da | |
dc.contributor.author | Gonzalez-Zorn, Bruno | |
dc.contributor.author | Barbé, Jordi | |
dc.contributor.author | Ploy, Marie-Cécile | |
dc.contributor.author | Mazel, Didier | |
dc.date.accessioned | 2021-03-09T16:42:07Z | |
dc.date.available | 2021-03-09T16:42:07Z | |
dc.date.issued | 2009-05-22 | |
dc.description.abstract | ntegrons are found in the genome of hundreds of environmental bacteria but are mainly known for their role in the capture and spread of antibiotic resistance determinants among Gram-negative pathogens. We report a direct link between this system and the ubiquitous SOS response. We found that LexA controlled expression of most integron integrases and consequently regulated cassette recombination. This regulatory coupling enhanced the potential for cassette swapping and capture in cells under stress, while minimizing cassette rearrangements or loss in constant environments. This finding exposes integrons as integrated adaptive systems and has implications for antibiotic treatment policies. | en_US |
dc.description.sponsorship | M.-C.P. acknowledges support by grants from the Ministère de l’Enseignement Supérieur et de la Recherche, the Conseil Régional du Limousin, the Fondation pour la Recherche Médicale (FRM), and Institut National de la Santé et de la Recherche Médicale; D.M. from the Institut Pasteur, the Centre National de la Recherche Scientifique, the FRM, and the European Union (STREP CRAB, LSHM-CT2005-019023); J.B. from the Spanish Ministerio de Ciencia e Innovación (MICINN) (BFU2008-01078/BMC) and the Catalunya Generalitat (2005SGR-533); and B.G.Z. from the MICINN (GEN2006-27767-E/PAT) and European Union (MED-VET-NET and FOOD-CT2004-506122). | en_US |
dc.description.uri | https://science.sciencemag.org/content/324/5930/1034.long | en_US |
dc.format.extent | 2 pages | en_US |
dc.genre | journal articles | en_US |
dc.identifier | doi:10.13016/m2atvo-g2wh | |
dc.identifier.citation | Guerin et al., The SOS Response Controls Integron Recombination, Science, Vol. 324, Issue 5930, pp. 1034 DOI: 10.1126/science.1172914 | en_US |
dc.identifier.uri | https://doi.org/10.1126/science.1172914 | |
dc.identifier.uri | http://hdl.handle.net/11603/21109 | |
dc.language.iso | en_US | en_US |
dc.publisher | AAAS | en_US |
dc.relation.isAvailableAt | The University of Maryland, Baltimore County (UMBC) | |
dc.relation.ispartof | UMBC Biological Sciences Department Collection | |
dc.rights | This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author. | |
dc.subject | integrons | en_US |
dc.subject | genome | en_US |
dc.subject | antibiotic resistance | en_US |
dc.subject | bacteria | en_US |
dc.subject | treatment | en_US |
dc.title | The SOS Response Controls Integron Recombination | en_US |
dc.type | Text | en_US |
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