The SOS Response Controls Integron Recombination

dc.contributor.authorGuerin, Émilie
dc.contributor.authorCambray, Guillaume
dc.contributor.authorSanchez-Alberola, Neus
dc.contributor.authorCampoy, Susana
dc.contributor.authorErill, Ivan
dc.contributor.authorRe, Sandra Da
dc.contributor.authorGonzalez-Zorn, Bruno
dc.contributor.authorBarbé, Jordi
dc.contributor.authorPloy, Marie-Cécile
dc.contributor.authorMazel, Didier
dc.date.accessioned2021-03-09T16:42:07Z
dc.date.available2021-03-09T16:42:07Z
dc.date.issued2009-05-22
dc.description.abstractntegrons are found in the genome of hundreds of environmental bacteria but are mainly known for their role in the capture and spread of antibiotic resistance determinants among Gram-negative pathogens. We report a direct link between this system and the ubiquitous SOS response. We found that LexA controlled expression of most integron integrases and consequently regulated cassette recombination. This regulatory coupling enhanced the potential for cassette swapping and capture in cells under stress, while minimizing cassette rearrangements or loss in constant environments. This finding exposes integrons as integrated adaptive systems and has implications for antibiotic treatment policies.en_US
dc.description.sponsorshipM.-C.P. acknowledges support by grants from the Ministère de l’Enseignement Supérieur et de la Recherche, the Conseil Régional du Limousin, the Fondation pour la Recherche Médicale (FRM), and Institut National de la Santé et de la Recherche Médicale; D.M. from the Institut Pasteur, the Centre National de la Recherche Scientifique, the FRM, and the European Union (STREP CRAB, LSHM-CT2005-019023); J.B. from the Spanish Ministerio de Ciencia e Innovación (MICINN) (BFU2008-01078/BMC) and the Catalunya Generalitat (2005SGR-533); and B.G.Z. from the MICINN (GEN2006-27767-E/PAT) and European Union (MED-VET-NET and FOOD-CT2004-506122).en_US
dc.description.urihttps://science.sciencemag.org/content/324/5930/1034.longen_US
dc.format.extent2 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2atvo-g2wh
dc.identifier.citationGuerin et al., The SOS Response Controls Integron Recombination, Science, Vol. 324, Issue 5930, pp. 1034 DOI: 10.1126/science.1172914en_US
dc.identifier.urihttps://doi.org/10.1126/science.1172914
dc.identifier.urihttp://hdl.handle.net/11603/21109
dc.language.isoen_USen_US
dc.publisherAAASen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjectintegronsen_US
dc.subjectgenomeen_US
dc.subjectantibiotic resistanceen_US
dc.subjectbacteriaen_US
dc.subjecttreatmenten_US
dc.titleThe SOS Response Controls Integron Recombinationen_US
dc.typeTexten_US

Files

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.56 KB
Format:
Item-specific license agreed upon to submission
Description: