IN VITRO REGULATION OF HUMAN T LYMPHOCYTE IMMUNE RESPONSES BY ADHERENT CELLS
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Date
1988-05
Type of Work
Department
Hood College Biology
Program
Biomedical and Environmental Science
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Abstract
Cytotoxic T lymphocyte (CTL) responses to Human Leukocyte Antigen
(HLA) alloantigens are unexpectedly weak compared to the CTL response
to influenza virus. Allogeneic CTL activity was increased dramatically
by removal of Leu M3+ cells by using adherence and phagocytic
properties of the macrophage/monocyte cell type. The Leu M3+ enriched
population was capable of suppressing the allogeneic CTL response
generated by adherent-depleted PBL. Pre-cultured cells suppressed both
allogeneic and influenza virus-specific CTL responses. Influenza virus
infection ameliorated the suppression through an unknown mechanism.