Akbari, EhsanMollica, Molly Y.Lucas, Christopher R.Bushman, Sarah M.Patton, Randy A.Shahhosseini, MelikaSong, Jonathan W.Castro, Carlos E.2023-08-142023-08-142017-10-13Akbari, Ehsan, Molly Y. Mollica, Christopher R. Lucas, Sarah M. Bushman, Randy A. Patton, Melika Shahhosseini, Jonathan W. Song, and Carlos E. Castro. “Engineering Cell Surface Function with DNA Origami.” Advanced Materials 29, no. 46 (2017): 1703632. https://doi.org/10.1002/adma.201703632https://doi.org/10.1002/adma.201703632http://hdl.handle.net/11603/29193A specific and reversible method is reported to engineer cell-membrane function by embedding DNA-origami nanodevices onto the cell surface. Robust membrane functionalization across epithelial, mesenchymal, and nonadherent immune cells is achieved with DNA nanoplatforms that enable functions including the construction of higher-order DNA assemblies at the cell surface and programed cell–cell adhesion between homotypic and heterotypic cells via sequence-specific DNA hybridization. It is anticipated that integration of DNA-origami nanodevices can transform the cell membrane into an engineered material that can mimic, manipulate, and measure biophysical and biochemical function within the plasma membrane of living cells.18 pagesen-USThis is the peer reviewed version of the following article: Akbari, Ehsan, Molly Y. Mollica, Christopher R. Lucas, Sarah M. Bushman, Randy A. Patton, Melika Shahhosseini, Jonathan W. Song, and Carlos E. Castro. “Engineering Cell Surface Function with DNA Origami.” Advanced Materials 29, no. 46 (2017): 1703632. https://doi.org/10.1002/adma.201703632, which has been published in final form at https://doi.org/10.1002/adma.201703632. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.Text