Yuen, Jonathan D.Baingane, AnkitHasan, QumrulShriver-Lake, Lisa C.Walper, Scott A.Zabetakis, DanielBreger, Joyce C.Stenger, David A.Slaughter, Gymama2019-06-112019-06-112019-05-06Jonathan D. Yuen, et.al, A Fully-Flexible Solution-Processed Autonomous Glucose Indicator, Scientific Reports 9, Article number: 6931 (2019) https://doi.org/10.1038/s41598-019-43425-xhttps://doi.org/10.1038/s41598-019-43425-xhttp://hdl.handle.net/11603/14045We present the first demonstration of a fully-flexible, self-powered glucose indicator system that synergizes two flexible electronic technologies: a flexible self-powering unit in the form of a biofuel cell, with a flexible electronic device - a circuit-board decal fabricated with biocompatible microbial nanocellulose. Our proof-of-concept device, comprising an enzymatic glucose fuel cell, glucose sensor and a LED indicator, does not require additional electronic equipment for detection or verification; and the entire structure collapses into a microns-thin, self-adhering, single-centimeter-square decal, weighing less than 40 mg. The flexible glucose indicator system continuously operates a light emitting diode (LED) through a capacitive charge/discharge cycle, which is directly correlated to the glucose concentration. Our indicator was shown to operate at high sensitivity within a linear glucose concentration range of 1 mM–45 mM glucose continuously, achieving a 1.8 VDC output from a flexible indicator system that deliver sufficient power to drive an LED circuit. Importantly, the results presented provide a basis upon which further development of indicator systems with biocompatible diffusing polymers to act as buffering diffusion barriers, thereby allowing them to be potentially useful for low-cost, direct-line-of-sight applications in medicine, husbandry, agriculture, and the food and beverage industries.9 pagesen-USThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.Attribution 4.0 International (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/biocompatible microbial nanocelluloseenzymatic glucose fuel cellglucose sensorLED indicatorText