Peercy, BradfordDeal, BreAsia Niclole2021-01-292021-01-292018-01-0111949http://hdl.handle.net/11603/20888We are investigating, through mathematical modeling and analysis, the signaling pathway of the FOXO-1 protein family transcription factors that involve the activation by Insulin Growth Factors (IGF) and Protein Kinase B (Akt). In doing so, it is important to know how the phosphorylation state of the FOXO-1 proteins causes the degeneration of muscular-skeletal fibers \cite{Wimmer}. In this paper, we will be modeling biochemical behaviors involving the FOXO-1 protein family and its effects in muscle atrophy. In studying muscle atrophy we consider how the nuclear to cytoplasm FOXO-1 ratio, the total FOXO-1, and the nuclear FOXO-1 effect the amount of degradation protein produced by FOXO-1 to breakdown the muscle volume, and the cross-sectional area of the muscle over the course of several days.application:pdfText