Burkey, MDWilson, LEMoore, RDLucas, GMFrancis, JGebo, KA2023-08-042023-08-042008-10-27Burkey, M., Wilson, L., Moore, R., Lucas, G., Francis, J. and Gebo, K. (2008), The incidence of and risk factors for MRSA bacteraemia in an HIV-infected cohort in the HAART era. HIV Medicine, 9: 858-862. https://doi.org/10.1111/j.1468-1293.2008.00629.xhttps://doi.org/10.1111/j.1468-1293.2008.00629.xhttp://hdl.handle.net/11603/29090Objectives To define the incidence and risk factors for methicillin resistant Staphylococcus aureus (MRSA) bacteraemia in an HIV-infected population. Methods From January 1, 2000 to December 31, 2004, we conducted a retrospective cohort study. We identified all cases of Staphylococcus aureus bacteraemia (SAB), including MRSA, among patients enrolled in the Johns Hopkins Hospital out-patient HIV clinic. A conditional logistic regression model was used to identify risk factors for MRSA bacteraemia compared with methicillin-sensitive SAB and no bacteraemia in unmatched (1:1) and matched (1:4) nested case-control analyses, respectively. Results Of 4607 patients followed for a total of 11 020 person-years (PY) of follow-up, 216 episodes of SAB occurred (incidence: 19.6 cases per 1000 PY), including 94 cases (43.5%) which were methicillin-resistant. The incidence of MRSA bacteraemia increased from 5.3 per 1000 PY in 2000–2001 to 11.9 per 1000 PY in 2003–2004 (P=0.001). Multivariate analysis demonstrated that independent predictors of MRSA bacteraemia (vs. no bacteraemia) were injection drug use (IDU), end-stage renal disease (ESRD) and CD4 count <200 cells/μL. Conclusions MRSA bacteraemia was an increasingly common diagnosis in our HIV-infected cohort, especially in patients with history of IDU, low CD4 cell count and ESRD.en-USThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.bacteremiaHIVMRSAsepsisStaphylococcus aureusText