Rouhakhtar, Pamela RakhshanSørensen, HolgerDeVylder, JordanMittal, VijayMortensen, Erik L.Michelsen, Niels M.Ekstrøm, MortenPitts, SteveMednick, Sarnoff A.Schiffman, Jason2023-08-232023-08-232016-12-08Rakhshan, Pamela, Holger Sørensen, Jordan DeVylder, Vijay Mittal, Erik L. Mortensen, Niels M. Michelsen, Morten Ekstrøm, Steven C. Pitts, Sarnoff A. Mednick, and Jason Schiffman. “Childhood Pegboard Task Predicts Adult-Onset Psychosis-Spectrum Disorder among a Genetic High-Risk Sample.” Schizophrenia Research 178, no. 1 (December 1, 2016): 68–73. https://doi.org/10.1016/j.schres.2016.08.017.https://doi.org/10.1016/j.schres.2016.08.017http://hdl.handle.net/11603/29340Motor abnormalities have been established as a core aspect of psychosis-spectrum disorders, with numerous studies identifying deficits prior to clinical symptom presentation. Additional research is needed to pinpoint standardized motor assessments associated with psychosis-spectrum disorders prior to illness onset to enhance prediction and understanding of etiology. With a long history of findings among people with diagnosable psychosis-spectrum disorders, but little research conducted during the premorbid phase, pegboard tasks are a viable and understudied measure of premorbid for psychosis motor functioning. In the current study, examining data from the Copenhagen Perinatal Cohort, the Simultaneous Pegs Test was performed with children (n = 244, aged 10–13) at genetic high risk for psychosis (n = 94) and controls (n = 150). Findings suggest that children who eventually developed a psychosis-spectrum disorder (n = 33) were less likely to successfully complete the task within time limit relative to controls (χ² (2, N = 244) = 6.94, p = 0.03, ϕ = 0.17). Additionally, children who eventually developed a psychosis-spectrum disorder took significantly longer to complete the task relative to controls (χ² (2, N = 244) = 7.06, p = 0.03, ϕ = 0.17). As pegboard performance is thought to tap both diffuse and specific brain networks, findings suggest that pegboard tests may be useful premorbid measures of motor functioning among those on a trajectory towards a psychosis-spectrum disorder.16 pagesen-USThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)https://creativecommons.org/licenses/by-nc-nd/4.0/Text