Li, HonggangBaum, Caitlin E.Cullum, Brian2024-09-042024-09-042006-10-23Li, Honggang, Caitlin E. Baum, and Brian M. Cullum. “Characterization of Novel Gold SERS Substrates with Multilayer Enhancements.” In Smart Medical and Biomedical Sensor Technology IV, 63800D. (October 23, 2006): 86–97. https://doi.org/10.1117/12.684688.https://doi.org/10.1117/12.684688http://hdl.handle.net/11603/36023Optics East 2006, 1-4 OCTOBER 2006, Boston, Massachusetts, United StatesA detailed study of SERS enhancements from novel multilayer gold film over nanoparticle (GFON) substrates is presented. These multilayer GFON substrates were optimized in terms of the number of metal layers, and the amounts of gold and silver oxide deposited. These multilayer GFON substrates were also structurally characterized in terms of surface roughness. No significant changes in the surface roughness of these multilayer GFON substrates, even with different layers of gold, have been observed, suggesting there is no direct correlation between the multilayer SERS enhancements and the surface roughness. UV-Vis reflectance spectra of these substrates were also characterized, indicating that the significant multilayer enhancements require the presence of silver oxide layers separating the continuous gold film layers.12 pagesen-US©2006 Society of Photo-Optical Instrumentation Engineers (SPIE)Text