Ashe, Jason J.Waldstein, Shari R.Singh, RupshaMaino Vieytes, Christian A.Beydoun, May A.Mode, NicolleGamaldo, AlyssaHampton Jarmon, MarshaBuxton, OrfeuEvans, Michele K.Zonderman, Alan B.2025-04-012025-04-012025-02-12Ashe, Jason J., Shari R. Waldstein, Rupsha Singh, Christian A. Maino Vieytes, May A. Beydoun, Nicolle Mode, Alyssa Gamaldo, et al. "Spirituality and Cardiovascular Health in the HANDLS Study: Evidence for Within-Race Differences.' Biopsychosocial Science and Medicine, 2025. 10.1097/PSY.0000000000001376. https://doi.org/10.1097/PSY.0000000000001376.http://hdl.handle.net/11603/37913Objective: This cross-sectional study explored the associations between spiritual transcendence (ST)—prayer/meditation fulfillment, connectedness, and universality— and the American Heart Association’s Life’s Simple 7 (LS7), and if variations across and within racial and socioeconomic groups emerged. Methods: Data were taken from the Healthy Aging in Neighborhoods of Diversity across the Life Span study and included 1110 midlife and older African American and white adults [mean (SD) age=56.13 (8.91) y; 65.0% above poverty; 78.1% ≥high school education]. ST was self-reported. LS7 comprised physical activity, smoking, diet, body mass index, cholesterol, glucose, and blood pressure. Higher LS7 reflects better cardiovascular health (CVH). Multiple linear regression estimated associations between ST and LS7. A 3-way interaction term (ST, race, and either education or poverty status) was included in models adjusted for sex and age. Results: A 3-way interaction was observed for ST, race, and poverty status (b=1.29, SE=0.35, p<.001). Simple slopes showed a positive association for white adults living above poverty only (b=0.54, SE=0.15, p<.001). Exploratory analyses found a nonlinear 3-way interactive effect including ST, race, and age (ie, U-shaped; b=0.04, SE=0.02, p=.048). Both lesser and greater ST were associated with higher LS7 for older African American adults exclusively (b=0.03, SE=0.01, p=.024). Conclusions: Although spirituality was associated with overall CVH, it was not beneficial for everyone equally. If tailored appropriately, the integration of spirituality into care practices may promote better CVH.34 pagesen-USThis work was written as part of one of the author's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.Public Domainhttps://creativecommons.org/publicdomain/mark/1.0/Text