Zhang, YanDas, Gautom KumarVijayaragavan, VimalanXu, Qing ChiPadmanabhan, ParasuramanBhakoo, Kishore K.Selvan, Subramanian TamilTan, Timothy Thatt Yang2024-03-142024-03-142014-08-08Zhang, Yan, Gautom Kumar Das, Vimalan Vijayaragavan, Qing Chi Xu, Parasuraman Padmanabhan, Kishore K. Bhakoo, Subramanian Tamil Selvan, and Timothy Thatt Yang Tan. “‘Smart’ Theranostic Lanthanide Nanoprobes with Simultaneous up-Conversion Fluorescence and Tunable T 1 – T 2 Magnetic Resonance Imaging Contrast and near-Infrared Activated Photodynamic Therapy.” Nanoscale 6, no. 21 (2014): 12609–17. https://doi.org/10.1039/C4NR01717J.https://doi.org/10.1039/C4NR01717Jhttp://hdl.handle.net/11603/32041The current work reports a type of “smart” lanthanide-based theranostic nanoprobe, NaDyF₄:Yb³⁺/NaGdF₄:Yb³⁺,Er³⁺, which is able to circumvent the up-converting poisoning effect of Dy³⁺ ions to give efficient near infrared (980 nm) triggered up-conversion fluorescence, and offers not only excellent dark T₂-weighted MR contrast but also tunable bright and T₁-weighted MR contrast properties. Due to the efficient up-converted energy transfer from the nanocrystals to chlorin e6 (Ce6) photosensitizers loaded onto the nanocrystals, cytotoxic singlet oxygen was generated and photodynamic therapy was demonstrated. Therefore, the current multifunctional nanocrystals could be potentially useful in various image-guided diagnoses where bright or dark MRI contrast could be selectively tuned to optimize image quality, but also as an efficient and more penetrative near-infrared activated photodynamic therapy agent.9 pagesThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.CC BY 3.0 DEED Attribution 3.0 Unportedhttps://creativecommons.org/licenses/by/3.0/Text