Aslan, KadirWu, MengLakowicz, Joseph R.Geddes, Chris2024-10-012024-10-012007-02-06Aslan, Kadir, Meng Wu, Joseph R. Lakowicz, and Chris D. Geddes. “Metal Enhanced Fluorescence Solution-Based Sensing Platform 2: Fluorescent Core-Shell Ag@SiO₂ Nanoballs.” Journal of Fluorescence 17, no. 2 (March 1, 2007): 127–31. https://doi.org/10.1007/s10895-007-0164-6.https://doi.org/10.1007/s10895-007-0164-6http://hdl.handle.net/11603/36571In this Rapid Communication, we present the development of monodisperse core-shell (silver core-silica shell) nanoparticles with various shell thicknesses featuring a fluorophore, subsequently named Metal-Enhanced Fluorescence (MEF) nanoballs. MEF nanoballs consist of a ≈130 nm silver nanoparticle core, a silica shell with up to 35 nm thickness and fluorophores doped within the silica shell. Fluorescent nanobubbles where the silver core is removed by chemical etching are used as control samples to show the benefits of using silver nanoparticles, i.e, Metal-Enhanced Fluorescence. Finally, we demonstrate the broad potential biological applications of MEF nanoballs by employing near-infra red emitting probes (Rhodamine 800) within the silica shell, for potential applications in cellular imaging and solution-based sensing.10 pagesen-USThis version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10895-007-0164-6PlasmonicsFluorescenceRadiative decay engineeringSilver colloidsSolution sensing platformNanoparticlesPlasmon enhanced luminescenceSilver nanoparticlesPlasmonSurface enhanced fluorescenceMetal-enhanced fluorescencePlasmon enhanced fluorescenceText