Browsing by Author "Shen, Botong"
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Item Associations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults(Nature, 2021-10-06) Weiss, Jordan; Hossain, Sharmin; Maldonado, Ana I.; Shen, Botong; Beydoun, Hind A.; Kivimaki, Mika; Evans, Michele K.; Zonderman, Alan B.; Beydoun, May A.We examined associations between cognition and mortality and how these relationships vary by race and Apolipoprotein E (APOE) genotype, in a longitudinal study of 2346 middle-aged White and African American adults (30–64 years at baseline) from the Healthy Aging in Neighborhoods of Diversity across the Life Span cohort study. Baseline cognition spanned global mental status, and several domains obtained using principal components analysis (PCA; PCA1: verbal memory/fluency; PCA2: attention/working memory; PCA3: executive function/visuo-spatial abilities). Cox regression models evaluated associations between cognition and all-cause and cardiovascular disease (CVD)-mortality. Interactions between cognition and APOE2 as well as APOE4 allelic dose were tested, and race was a key effect modifier. Higher APOE4 dose was associated with increased CVD-mortality (hazard ratio [HR] per allele = 1.37; 95% CI 1.01–1.86, p = 0.041); APOE2 dosage’s association with CVD-mortality was non-significant (HR = 0.60; 95% CI 0.35–1.03, p = 0.065). Higher PCA3 was associated with lower all-cause (HR = 0.93; 95% CI 0.87–0.99, p = 0.030) and CVD (HR = 0.85; 95% CI 0.77–0.95, p = 0.001) mortality risks, the latter association being more pronounced among Whites. PCA2 interacted synergistically with APOE2 dosage, reducing risks for all-cause mortality (PCA2 × APOE2: − 0.33 ± 0.13, p = 0.010) and CVD mortality (PCA2 × APOE2: − 0.73 ± 0.31, p = 0.019). In conclusion, greater executive function/visuo-spatial abilities were associated with reduced CVD-specific mortality, particularly among Whites. Greater “attention/working memory” coupled with higher APOE2 dosage was linked with reduced all-cause and CVD mortality risks.Item Race, APOE genotypes, and cognitive decline among middle-aged urban adults(BioMed Central, 2021-06-30) Beydoun, May A.; Weiss, Jordan; Beydoun, Hind A.; Hossain, Sharmin; Maldonado, Ana I.; Shen, Botong; Evans, Michele K.; Zonderman, Alan B.Background Associations of Apolipoprotein (APOE) ε₂ or ε₄ (APOE₂ or APOE₄) dosages with cognitive change may differ across racial groups. Methods Longitudinal data on 1770 middle-aged White and African American adults was compiled from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS 2004-2013) study. APOE₂ and APOE₄ dosages were the two main exposures, while v₁ and annual rate of change in cognitive performance (between v₁ and v₂) on 11 test scores were the main outcomes of interest (v1: 2004–2009 and v2: 2009–2013). Mixed-effects linear regression models were conducted adjusting for socio-demographic, lifestyle, and health-related potential confounders. Race (African American vs. White) and sex within racial groups were main effect modifiers. Results Upon adjustment for multiple testing and potential confounders, APOE₄ allelic dosage was associated with faster decline on a test of verbal memory among Whites only (CVLT-List A: γ₁₂ = − 0.363 ± 0.137, p = 0.008), but not among African Americans. In contrast, among African American women, APOE₄ dosage was linked to slower decline on a test of attention (BTA: γ₁₂ = + 0.106 ± 0.035, p = 0.002), while no association was detected among African American men. APOE₂ and APOE₄ dosages showed inconsistent results in other domains of cognition overall and across racial groups that did not survive correction for multiple testing. Conclusions In conclusion, APOE₄ dosage was associated with faster decline on a test of verbal memory among Whites only, while exhibiting a potential protective effect among African American women in the domain of attention. Further longitudinal studies are needed to replicate our race and sex-specific findings.