Browsing by Subject "Bacteriophages"
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Item Complete genome sequences of 138 mycobacteriophages(American Society for Microbiology, 2012-01-26) Hatfull, Graham F.; the Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science Program; the KwaZulu-Natal Research Institute for Tuberculosis and HIV Mycobacterial Genetics Course Students; the Phage Hunters Integrating Research and Education Program; Caruso, StevenBacteriophages are the most numerous biological entities in the biosphere, and although their genetic diversity is high, it remains ill defined. Mycobacteriophages-the viruses of mycobacterial hosts-provide insights into this diversity as well as tools for manipulating Mycobacterium tuberculosis. We report here the complete genome sequences of 138 new mycobacteriophages, which-together with the 83 mycobacteriophages previously reported-represent the largest collection of phages known to infect a single common host, Mycobacterium smegmatis mc² 155.Item SURVEY OF BACTERIOPHAGE FROM THE ENVIRONMENT AND EFFECTIVENESS FOR CONTROLLING ESCHERICHIA COLI 0157: H7 ON ICEBERG LETTUCE(2020-04-05) deWitt, John; Smith, Oney; Boyd, Ann; Laufer, Craig; Biology; Biomedical SciencesApproximately one third of foodborne illnesses are due to pathogenic, hemorrhagic O157 Escherchia. coli bacteria. Symptoms of this infection are gastrointestinal in nature and range from mild to severe in intensity. The focus of this project will be to discover wild bacteriophages that control O157:H7 or O157 strains of E. coli without harming non-pathogenic E. coli. To do so, soil and water samples where ruminant animals dwell will be collected. These viruses will be purified and cultured from these samples, and the virulence, cross infectivity, and genetic characteristics of the viruses will be determined. Lastly, a direct study of the virulent wild phages in a mock food contamination setting will be examined to determine if the wild bacteriophages collected are just as effective in controlling O157 E. coli as a common commercial strain is.