Browsing by Subject "Contractile cardiac dynamics"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
Item Examining the Effect of Introducing a Link from Electrical Excitation to Calcium Dynamics in a Cardiomyocyte(Illinois State University, 2016) Angeloff, Kallista; Barajas, Carlos A.; Middleton, Alexander; Osia, Uchenna; Graf, Jonathan S.; Gobbert, Matthias K.; Coulibaly, ZanaCalcium dysregulation is a signi cant cause of fatal cardiac arrythmias, but it is an incompletely understood phenomenon and diffcult to predict. Cardiac calcium levels can be modeled as a system of partial differential equations linking the electrical excitation, calcium signaling, and mechanical contraction dynamics of the heart. A complete calcium-induced calcium release model uses reaction-diffusion equations to fully link these three systems. Simulations examine the effect of introducing the link from calcium signaling to electrical excitation. In particular, we perform a parameter study on the strength of the feedback connection with both links between calcium signaling and electrical excitation enabled. Simulations indicate that the feedback and feedforward between electrical excitation and calcium signaling can in uence the voltage in a physiologically realistic way.Item Modeling the Links Between the Chemical, Electrical and Contractile Calcium Dynamics in a Heart Cell(2016) Angeloff, Kallista; Barajas, Carlos; Middleton, Alexander; Osia, Uchenna; Graf, Jonathan S.; Gobbert, Matthias K.; Coulibaly, ZanaCalcium dysregulation is a signi cant cause of fatal cardiac arrythmias, but it is an incompletely understood phenomenon and diffcult to predict. Cardiac calcium levels can be modelled as a system of partial differential equations linking the electrical, calcium, and mechanical dynamics of the heart. Earlier work on this subject established a model linking the chemical and electrical systems, which did not include the contractile or mechanical in uence. We have expanded the most recent extant model to include the mechanical aspect of calcium dynamics in the heart.