Browsing by Subject "HIV cure"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
Item CHARACTERIZATION OF THE HIV-1 PROVIRAL LANDSCAPE IN PERINATALLY INFECTED EARLY TREATED CHILDREN ON LONG-TERM ANTIRETROVIRAL THERAPY(2022) Hasson, Jenna; Kearney, Mary; Patro, Sean; Boyd, Ann; Hood College Biomedical ScienceAntiretroviral therapy (ART) prevents disease progression in people living with Human Immunodeficiency Virus (HIV) (PLWH). However, off-target effects can result in liver disease, heart disease, diabetes, and more, and there is no accessible cure for the virus. Therefore, understanding the mechanisms for HIV persistence on ART is important to inform strategies for the development of future potential curative inventions. Studies investigating the genetics of integrated HIV genomes (proviruses) in adults revealed the sources of low-level viremia and informed new targets for possible curative strategies. However, little is known about the effect of HIV and long-term ART on the developing immune systems of infants and children. Differences between the immune systems of adults and children may influence mechanisms of viral persistence and immune control, which may be reflected by differences in the HIV proviral genetics. The aim of this thesis research was to characterize the HIV proviral genetic landscape in children on long-term ART and compare it to infants on short-term ART, children on short-term ART, and adults on long-term ART to elucidate any potential differences in the proviral populations that may inform new targets for future cure interventions.Item A landscape analysis of HIV cure-related clinical trials and observational studies in 2018(2019-11) Barr, Liz; Jefferys, RichardObjectives: The community-based organisation Treatment Action Group has established an online listing of HIV curerelated trials and observational studies derived from trial registries. Our objective was to use the listing as a basis for a landscape analysis of the current status of HIV cure-related clinical research. Methods: Trials and observational studies listed as of August 2018 formed the sample set. Survey questions were developed on trial development, trial design, recruitment, enrolment, study completion and dissemination plans. A survey was sent to the contact(s) for each study. Supplemental information was collected from clinicaltrials.gov. The full dataset was then analysed. Results: A total of 99 interventional trials and 29 observational studies were included. Diverse interventions are under evaluation, including combinations of experimental candidates. Current studies plan to enrol over 7000 participants. Projected completion dates for ~90% of the sample fell between the fourth quarter of 2018 and the end of 2020. Potential obstacles to enrolment that were reported included concerns over invasive procedures and lack of potential benefit to participants. Data on the sex and ethnicity of enrollees were limited but sufficient to note a significant underrepresentation of women. Conclusions: A considerable amount of HIV cure-related clinical research is under way. The results from these studies, which should help shape the future of the field, will become available over the next 2–4 years. Diversity both geographically and in terms of enrollees remains limited, particularly in terms of the participation of women, a concern that could significantly affect the generalisability of the findings.